Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis

Inclusion Criteria:

• Age between 18 and 70 years

• Nonpregnant or breast-feeding women

• ECOG status 0-1

• Colorectal adenocarcinoma or mucinous adenocarcinoma;

• Intraoperative confirmed cT4N0-2M0 Colorectal cancer (visual determination - accordingto AJCC 8th edition) without previous anti-cancer treatment and R0 resection could beachieved

• Laboratory tests within 2 weeks before Randomization：Neutrophil ≥ 2.0 /mm3, ,platelets ≥ 100,000/mm3, hemoglobin≥90g/l, Alanine transaminase (ALT) and aspartateaminotransferase (AST) ≤ 2.5 ×ULN), total bilirubin(TBIL)≤ 1.5 × ULN, serum creatinine ≤ 1.5 ×ULN

• Written informed consent

Exclusion Criteria:

• Rectal cancer below peritoneal reflection

• Concurrent with or have other cancer within the past 5 years ( except for skin basalcell carcinoma, or cervical carcinoma in situ, who have received radical treatment)

• Severe abdominal infection or extensive fibrosis of peritoneal cavity that lead toimpossible separation

• Surgical procedures conversion(from robotic or laparoscopic surgery to laparotomy) oremergency surgery due to perforation or obstruction

• Existence of distance metastasis during surgery (M1) or can not achieve R0 resection

• Contraindiction of mitomycin c(chickenpox or shingles)

• Poorly controlled respiratory or cardiac disease, severe hepatic or renaldysfunction,drug abuse or uncontrolled mental disease