The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study

Last updated: January 6, 2023
Sponsor: Fraser Health
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04360070
001
  • Ages > 19
  • All Genders

Study Summary

Recent evidence suggests ketamine may attenuate harmful cellular cascades taking place after brain injury that result in permanent damage. The investigators are interested in researching the application of this in the setting of cardiac arrest. Following cardiac arrest, the brain is deprived oxygen for a period of time, leading to the imitation of these harmful cellular processes. The investigators hypothesize that patients who receive ketamine as part of their standard sedation procedures during cardiac arrest treatment have better neurological functioning compared to those who do not.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All out-of-hospital cardiac arrests (OHCA) with a "shockable rhythm" (ventricularfibrillation, pulseless ventricular tachycardia) that present to the Royal ColumbianHospital. The patient may be either in active cardiac arrest with shockable rhythm ormay have achieved Return of Spontaneous Circulation (ROSC).
  • Over 19 years of age
  • Patients requiring sedation based on the assessment of the resuscitating physician.

Exclusion

Exclusion Criteria:

  • Any other type of cardiac arrest
  • Any history of previous, pre-existing neurological deficit
  • Started on Extracorporeal Membrane Oxygenation (ECMO)
  • Duration of cardiac arrest without ROSC is greater than 30 consecutive minutes
  • Known contraindication or hypersensitivity to ketamine
  • Awake patient or no standard sedation or no intubation required
  • Inability to obtain deferred consent
  • Currently enrolled in any other research study involving drugs or devices
  • Patients who are pregnant
  • Patients who are prisoners
  • Patients residing in Long Term Care (LTC) facilities

Study Design

Total Participants: 24
Study Start date:
February 28, 2022
Estimated Completion Date:
December 12, 2023

Connect with a study center

  • Fraser Health Authority - Royal Columbian Hospital

    New Westminster, British Columbia V3L 3W7
    Canada

    Active - Recruiting

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