Hydroxychloroquine Plus Azithromycin Versus Hydroxychloroquine for COVID-19 Pneumonia (COVIDOC Trial)

Inclusion Criteria:

• 18-75 years old SARS CoV-2 Infection confirmed by positive virologic test realised inthe 96 h before randomization
• Beginning of COVID-19 symptoms < 10 days at the time of randomization
• Presence of symptom(s) of COVID-19 : fever (température > or = 37,5°C) or respiratorysign(s) (cough, breathing discomfort) or recent anosmia
• Presence of TDM/radiographic signs or pneumonia
• Hospitalization out of ICU for COVID with: moderate clinical form (no oxygenotherapy)or non critical severe form (oxygenotherapy)

Exclusion Criteria:

• Absence of signed informed consent
• SpO2 < 90 % ambient air or < 94 % with oxygenotherapy > or = 3l/min
• Need of oxygenotherapy > 6 l/min or mechanical ventilation
• Need of hospitalization in ICU
• ALAT/ASAT > 5 LSN
• Renal failure (eGFR < 40 ml/min ) or dialysis
• Pregnancy or breastfeeding
• Retinopathy
• Known deficit in G6PD
• Cardiac rythm / lengthening QT disorders
• QT space lengthening on ECG with QTc > 450 ms
• Concomitant treatment :citalopram, escitalopram, hydroxyzine, domperidone,pipéraquine, anti-arhythmic class IA & III, antidepressive drugs,..