Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment

Inclusion Criteria:

• Be at least 18 years of age;
• Provide written informed consent;
• Have a reported history of dry eye for at least 6 months prior to enrollment;
• Have a history of use of eye drops

Exclusion Criteria:

• Have any clinically significant slit lamp findings at Visit 1 that may include activeblepharitis, meibomian gland dysfunction (MGD), lid margin inflammation or activeocular allergies that require therapeutic treatment, and/or in the opinion of theinvestigator may interfere with study parameters;
• Be diagnosed with an ongoing ocular infection (bacterial, viral, or fungal), or activeocular inflammation at Visit 1;
• Have worn contact lenses within 7 days of Visit 1 or anticipate using contact lensesduring the study;
• Have used any eye drops within 2 hours of Visit 1;
• Have previously had laser-assisted in situ keratomileusis (LASIK) surgery within thelast 12 months;
• Be a woman of childbearing potential who is not using an acceptable means of birthcontrol; acceptable methods of contraception