Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer

Last updated: April 28, 2025
Sponsor: Emory University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Small Cell Lung Cancer

Treatment

Proton-beam Therapy for Small Cell Lung Cancer

Clinical Study ID

NCT04342429
IRB00110109
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

To assess the safety and efficacy of intensity-modulated proton therapy (IMPT) for small cell lung cancer (SCLC)

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Pathologically confirmed small cell lung cancer, limited or extensive stage.

  • Patients who are offered thoracic radiotherapy with intensity-modulated protontherapy (IMPT) techniques delivering 30-66 Gy in 15-33 fractions at 2 Gy perfraction, at the recommendation of the treating radiation oncologist.

  • Age 18 or greater

Exclusion

Exclusion Criteria:

  • Prior radiation therapy which would provide significant dose overlap with theplanned target volume(s)

  • Pregnancy

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Proton-beam Therapy for Small Cell Lung Cancer
Phase:
Study Start date:
March 19, 2020
Estimated Completion Date:
May 27, 2026

Study Description

To determine the optimal schedule for three-dimensional verification imaging and necessary re-planning of patients undergoing IMPT for a rapidly changing tumor (small cell lung cancer).

  • To determine the rate of cardiac toxicities from IMPT in patients with small cell lung cancer compared with historical controls receiving photon-based treatment.

  • To determine the rate of pneumonitis and esophagitis from IMPT and compare with historical controls receiving photon based treatment.

Connect with a study center

  • Winship Cancer Institute

    Atlanta, Georgia 30322
    United States

    Active - Recruiting

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