A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonist) In Participants With Unresectable Advanced Or Metastatic Hepatocellular Carcinoma, Biliary Tract Cancer, Or Solid Tumors With Hepatic Metastases

Inclusion Criteria:

• Histologically confirmed diagnosis of one of the following: unresectable advanced ormetastatic HCC (including fibrolamellar HCC) not amenable to a curative treatmentapproach, unresectable advanced or metastatic intrahepatic or perihilar (Klatskin)BTC not amenable to a curative treatment approach, extrahepatic BTC or gallbladdercancer infiltrating the liver or metastasized into the liver with predominant liverdisease, not amenable to a curative treatment approach, metastasized colorectalcancer (CRC), pancreatic ductal adenocarcinoma (PDAC), Gastric cancer (GC), renalcell carcinoma (RCC), triple negative breast cancer (TNBC), cutaneous melanoma, orocular melanoma with predominant liver disease not amenable to a curative treatmentapproach. Participants with other solid tumors with predominant liver disease notamenable to a curative treatment approach might be enrolled after Sponsor approval

• Measurable disease with at least one measurable locally untreated liver lesion, asdefined by RECIST v1.1

• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

• Adequate hematologic and major organ functions

• Participants for which there is no available standard therapy likely to conferclinical benefit, or participants who are not candidates for such available therapy

• Life expectancy of ≥12 weeks, approximated with Royal Marsden Hospital score 0-1 orGustave Roussy Immune (GRIm) score 0-1. Participants with a Royal Marsden Hospitalor GRIm score of ≥2 and a life expectancy of ≥12 weeks according to theinvestigator's clinical judgement may be enrolled after Medical Monitor approval hasbeen obtained.

• For participants with HCC: Child-Pugh score of A6 or better

Exclusion Criteria:

• History or clinical evidence of central nervous system (CNS) primary tumors ormetastases including leptomeningeal metastases, unless they have been previouslytreated, are asymptomatic, and have had no requirement for steroids orenzyme-inducing anticonvulsants in the last 14 days prior to Screening

• Evidence of any extra-hepatic primary tumor or metastasis requiring prompt medicalintervention

• Receipt of prior therapy with a TLR7/8/9 agonist and/or IFN-alpha

• Prior chemotherapy, antibody, or other registered or experimental cancer treatmentwithin 3 weeks of study Cycle 1 Day 1. Specifically, no CPI antibody is allowed tobe administered within 6 weeks of study Cycle 1 Day 1

• Receipt of investigational agent for any other indication within 3 weeks of dosing

• Treatment with systemic immunosuppressive medication (including, but not limited to,corticosteroids, cyclophosphamide, azathioprine, methotrexate, thalidomide, andanti-TNF-alpha agents) within 2 weeks prior to initiation of study treatment, oranticipation of need for systemic immunosuppressive medication during studytreatment

• Local therapy to liver (e.g. radiofrequency ablation, percutaneuous ethanol oracetic acid injection, cryoablation, high-intensity focused ultrasound,transarterial chemoembolization, and transarterial embolization) within 3 weeksprior to initiation of study treatment, radioembolization within 3 months prior toinitiation of study treatment, or non-recovery from side effects of such procedure

• Treatment-related toxicities from prior cancer therapy that have not resolved to </=Grade 1 CTC AE prior to study treatment with the exception of the following Grade 2toxicities:

alopecia, peripheral neuropathy, any laboratory changes that still lie within the inclusion criteria defined above

• History of other malignancy within 2 years; exception for ductal carcinoma in situnot requiring chemotherapy, low grade cervical intraepithelial neoplasia (CIN),nonmelanoma skin cancer, low grade localized prostate cancer (Gleason score < Grade 7), or optimally treated Stage 1 uterine cancer.

• Active or history of immunologic-mediated disease, including but not limited tomyasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus,rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease,antiphospholipid antibody syndrome, Wegener granulomatosis, Sjogren's syndrome orGuillain-Barré syndrome

• Known active or uncontrolled bacterial, viral, fungal, mycobacterial, parasitic, orother infection.

• Ascites, pleural effusion, or pericardial effusion requiring medical interventionwithin 12 months prior to study entry.

• History of human immunodeficiency virus (HIV) infection

• Active hepatitis B virus (HBV) infection

• Coinfection of HBV and hepatitis C virus (HCV).