Is Routine Dissection of Central Lymph Node Necessary for Papillary Thyroid Carcinoma, T1-2 N0?

Phase

N/A

Condition

Carcinoma

Thyroid Disorders

Treatment

N/A

Clinical Study ID

NCT04336696

0000-0002-9836-9580

Ages 42-55
All Genders
Accepts Healthy Volunteers

Study Summary

study assigned into three groups, Group I was the control group operated by total thyroidectomy and retrospectively followed, where the other two groups Operated by Total thyroidectomy and central neck dissection. Recurrence Free Survival (RFS) was the main issue of the study and calculated as the time from date of surgery to date of relapse or the most recent follow-up contact that patient was known as relapse-free, Study exclusively studied the outcome and advantage of central neck dissection

Eligibility Criteria

Inclusion

Inclusion Criteria:

Age ≥20 years, Histopathology proved PTC, with no lymph nodes detected (N0)

Exclusion

Exclusion Criteria:

Younger age ≤20 years. Prior thyroidectomy, previous radiation exposure, postoperativeradioactive iodine therapy, Histopathology report of any type of malignancy other thanPTC or patients did not complete their postoperative follow-up period. PTC With N1 orN2

Study Design

November 02, 2016

May 03, 2020

Study Description

informed consent taken, study was a prospective cohort study, with controlled group a retrospectively. patients ablated by total thyroidectomy only who failed to achieve ablation with the first dose of iodine 131I may be dynamically risk stratified as high-risk category and managed aggressively. N0 patients will benefit and ablated by total thyroidectomy and prophylactic central neck dissection, PCND decreases the residual, increase the RFS and patients without residual do not need adjuvant RAI therapy except in high risk group. Histological grading, size of the primary tumour, the extension of PTC, the extent of surgery were found to be a strong predicting factor for recurrence-free survival

Locoregional recurrence cases always found more in male patients aged more than 45 years old. Size of the primary tumour and the extent of surgery was a significant factor for RFS,

Connect with a study center

Zagazig University Hospitals
Zagazig, 13
Egypt
Active - Recruiting

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