Cambridge 7 Tesla Cerebral Small Vessel Disease Study

Last updated: September 19, 2022
Sponsor: University of Cambridge
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Treatment

N/A

Clinical Study ID

NCT04330222
A095132
  • Ages 18-99
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust.

We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Symptomatic lacunar stroke with corresponding lacunar infarct on MRI

Exclusion

Exclusion Criteria:

  1. Unable/unwilling to consent;
  2. Age<18;
  3. Stroke aetiology due to cardio-embolism or large vessel disease;
  4. Lacunar infarcts >1.5cm;
  5. Severe stroke (NIHSS score ≥16);
  6. Evidence of cortical infarct of any size;
  7. Other major neurological diseases;
  8. Severe systemic diseases such as heart failure, liver failure and kidney failure orany illness in the judgement of the investigator that could affect participation inthe study;
  9. MRI contraindications e.g. metal objects in or on the body, claustrophobia, pregnancy,known allergy to gadolinium containing contrast agent, impaired renal function withestimated glomerular filtration rate (eGFR) <59ml/min/1.73m2.

Study Design

Total Participants: 210
Study Start date:
March 09, 2020
Estimated Completion Date:
January 12, 2024

Connect with a study center

  • University of Cambridge

    Cambridge, Cambridgeshire CB2 0QQ
    United Kingdom

    Active - Recruiting

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