Association of Copy Number Variations in the SMN Genes With Acute Kidney Injury After Heart Surgery

Last updated: May 9, 2020
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Renal Failure

Kidney Disease

Kidney Failure

Treatment

N/A

Clinical Study ID

NCT04317196
XHEC-C-2019-111
  • Ages 1-80
  • All Genders

Study Summary

This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. This study also aims to analysis the effect of SMN1+/- genotype on postoperative AKI and the development of chronic kidney disease, as well as dose-compensating effect of different copy number of SMN2 gene on SMN1 +/- genotype.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age: Children (1 month -17 years old) and adults (18-80 years old);

  • Sex: All;

  • Those who will receive selective cardiac surgery with cardiopulmonary bypass;

  • Those who signed the informed consent.

Exclusion

Exclusion Criteria:

  • Those with glomerular filtration rate: eGFR<15ml/min/1.73m2, and those who havereceived the renal replacement therapy before surgery;

  • Those who have received nephrectomy and kidney transplantation;

  • Those who have suffered from AKI before;

  • Those with incomplete medical history or clinical data.

Study Design

Total Participants: 1206
Study Start date:
April 01, 2020
Estimated Completion Date:
September 01, 2022

Study Description

This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. Real-time PCR is used to detect copy number variations in the peripheral blood SMN gene on 1206 patients with heart surgery. This study also aims to analysis the effect of SMN1+/- genotype on postoperative AKI and the development of chronic kidney disease, as well as dose-compensating effect of different copy number of SMN2 gene on SMN1 +/- genotype.

Connect with a study center

  • Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

    Shanghai,
    China

    Active - Recruiting

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