Stem Cell and Conditioned Medium for Cerebral Palsy

Phase

1/2

Condition

Cerebral Palsy

Cataplexy

Treatment

Standard Therapy

Conditioned Medium

Umbilical Cord Mesenchymal Stem Cells

Clinical Study ID

NCT04314687

CT/CP/02/2020

Ages 6-3
All Genders

Study Summary

The aim of this study was to compare the effectiveness of umbilical cord mesenchymal stem cells (UCMSCs) and conditioned medium (CM) administration, UCMSCs only and control with standard therapy.

Hypothesis: UCMSCs + CM therapy resulting in higher improvement in cognitive function, gross motor function and chemical factors than UCMSCs and standard therapy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Diagnosed as Cerebral palsy with total body involvement type
Age between 6 month - 3 years old
Parents requesting for cell therapy
The parents give sign in informed consent form do to examination, therapy, bloodsampling collection and observation for their child

Exclusion

Exclusion Criteria:

Head circumference less than -3 SD (more than 3 cm) Nellhaus standard
Have diagnosed meningitis and encephalitis
Have diagnosed congenital infection i.e. toxoplasmosis, rubella congenital,cytomegalovirus
Have diagnosed metabolic disorder, chromosome disorder, congenital malformation orneuroregeneratif disease
Progressive disorder
Regressive development disorder
Severe anatomical abnormalities in Brain MRI

Study Design