Efficacy of Red Light in the Treatment of Pigmentary Disorders

Last updated: March 11, 2020
Sponsor: University of British Columbia
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vitiligo

Rash

Warts

Treatment

N/A

Clinical Study ID

NCT04308421
H20-00293
  • Ages > 18
  • All Genders

Study Summary

Pigmentary disorders such as melasma, lichen planus pigmentosus and vitiligo can significantly affect patients' quality of life. Treatment responses are usually slow and typically have limited efficacy. In recent years, low level laser therapy has been an emerging treatment modality for androgenetic alopecia, acne, wound healing and photorejuvenation. This is a prospective, double-blind, split-body, randomized controlled trial assessing the efficacy of low level laser therapy with red light for pigmentary disorders such as, melasma, lichen planus pigmentosus and vitiligo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants must be 18 years or older.

  • Participants should be competent to give fully informed consent by themselves

  • Should have received a diagnosis of either melasma, lichen planus pigmentosus orvitiligo either clinically or pathologically and have bilateral facialhyperpigmentation/depigmentation or bilateral similar sized depigmented/hyperpigmentedpatches or a single patch larger than 25 cm2.

  • Participants must stop receiving topical treatments or phototherapy 4 weeks prior tocommencing the study

Exclusion

Exclusion Criteria:

  • Known photosensitivity disorder

  • Unable to attend follow up appointments or twice weekly treatments

Study Design

Total Participants: 45
Study Start date:
March 01, 2020
Estimated Completion Date:
September 30, 2020

Study Description

This will be a participant and evaluator blinded trial with random allocation of one side of the face or affected area to treatment and the contralateral side as control. Random allocation of the treatment side will be performed using randomization software. Participants will be treated twice a week for 12 weeks with low irradiation 650 nm +/- 5 nm red light and followed up 4 weeks after completion of treatment. A trained blinded evaluator will assess clinical outcomes on week 4, week 8, week 12 and at follow up at week 16, using validated scores.

Connect with a study center

  • The Skin Care Centre, Vancouver General Hospital

    Vancouver, British Columbia V5Z 4E8
    Canada

    Active - Recruiting

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