Acute High Fat Bulletproof Coffee vs Black Coffee on Metabolism, Inflammation and Cognitive Function in Healthy Adults

Last updated: March 11, 2020
Sponsor: University of British Columbia
Overall Status: Active - Recruiting

Phase

N/A

Condition

Inflammation

Brain Function

White Cell Disorders

Treatment

N/A

Clinical Study ID

NCT04307979
Bulletproof Coffee
H19-02684
  • Ages 18-55
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study will determine whether acute ingestion of a high fat "Bulletproof Coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Must be over the age of 18

  • Must drink between 1-4 cups of coffee per day (on average)

  • Must be able to tolerate lactose and dairy products

  • Have not been sick for the past 3 weeks (immune function)

  • Non smoker

  • Must be able to fast for 10-12 hours

Exclusion

Exclusion Criteria:

  • If you are required to take corticosteroids (immune function)

  • Cannot understand or speak English

  • Individual has an auto-immune disease and requires medication

  • Individual is following a ketogenic diet

  • Individual has allergy or sensitivity to dairy, coffee or caffeine or coconut oil

  • Individual has hypertension

Study Design

Total Participants: 20
Study Start date:
January 01, 2020
Estimated Completion Date:
December 31, 2020

Study Description

In a randomized crossover design, participants will consume a single bulletproof coffee or a single black coffee separated by ~7 days. Each visit commences in the morning after an overnight fast of 10-12 hours, with no exercise the day prior, no coffee consumption the morning of testing, and completion of a food log for dietary duplication prior to visit 2. A fasting blood draw is obtained and cognitive function tests administered, along with questionnaires to assess gastrointestinal distress, arousal, and hunger/fullness before coffee consumption. Following this, one of the coffee beverages is consumed (randomized to each visit). Cognitive testing and questionnaires are completed at 60 minutes after finishing the coffee, another blood draw at 90 minutes, and then cognitive testing, questionnaires and a final blood draw 180 minutes after consuming the coffee. This procedure is repeated during their second experimental visit, in which they consume the remaining coffee based on their randomization.

Connect with a study center

  • University of British Columbia, Okanagan.

    Kelowna, British Columbia V1V 1V7
    Canada

    Active - Recruiting

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