Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema

Last updated: September 1, 2020
Sponsor: Massachusetts General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Disease

Lung Injury

Treatment

N/A

Clinical Study ID

NCT04288219
2019P003234
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy adults (age 18-80)

  • Travel through Pheriche, Nepal

  • Diagnosis of HAPE by symptoms, vital signs, and lung ultrasound

Exclusion

Exclusion Criteria:

  • History of chronic respiratory conditions (asthma, COPD, ILD)

  • Concomitant pneumonia or aspiration, cardiomyopathy, congestive heart failure

  • Kidney disease

  • Neurologic disorder

  • Cognitive disorder

  • Temporary altered mental status

  • Use of phosphodiesterase inhibitors or nifedipine prior to diagnosis of HAPE

  • Age under 18 or over 80

  • Pregnancy

Study Design

Total Participants: 16
Study Start date:
March 01, 2020
Estimated Completion Date:
June 30, 2021

Study Description

Patients in the Everest area will assessed for evidence of acute HAPE. Subjects will be randomized and assigned to standard care options or treatment with Non-Invasive Positive Pressure Ventilation.

Connect with a study center

  • Himalayan Rescue Association

    Kathmandu,
    Nepal

    Active - Recruiting

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