Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Inclusion Criteria:

1. Participant is < 21 years of age

2. Parent/ Legal Guardian/ Adult Participant can understand the consent process and iswilling to provide informed consent/HIPAA:

3. (a) Participant is receiving one or more of the study drugs of interest at the timeof enrollment or (b) Participant is NOT receiving one or more of the study drugs ofinterest but is SARS-COV-2 positive within 60 days prior to enrollment

Exclusion Criteria:

1. Participant has a known pregnancy Below exclusion criteria apply only to: Participants receiving one or more of the study drugs of interest at the time ofenrollment, DOI administration or PK sampling: (Refer to DOI specific appendices fordetails on enrollment cohort specifications and additional eligibility criteria)

2. Has had intermittent dialysis within previous 24 hours

3. Has had a kidney transplant within previous 30 days

4. Has had a liver transplant within previous 1 year

5. Has had a stem cell transplant within previous 1 year

6. Has had therapeutic hypothermia within previous 24 hours

7. Has had plasmapheresis within the previous 24 hours

8. Has a Ventricular Assist Device

9. Has any condition which would make the participant, in the opinion of theinvestigator, unsuitable for the study