Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies

Key Inclusion Criteria:

• Confirmed diagnosis of one of the following:

NHL Cohorts:

1. MZL i. R/R extranodal, splenic, or nodal MZL defined as disease that relapsed after,or was refractory to, at least one prior therapy ii. Active disease requiringtreatment

2. FL i. R/R FL (Grade 1, 2 or 3a based on the WHO 2008 classification of tumors ofhematopoietic and lymphoid tissue) and defined as disease that relapsed after, orwas refractory to, at least 1 prior systemic therapy

3. DLBCL i. R/R DLBCL (including all subtypes of DLBCL) defined as disease thatrelapsed after, or was refractory to, at least two prior systemic therapies and haseither progressed following or is not a candidate for autologous stem celltransplant (due to comorbidities or non-responsiveness to salvage chemotherapy)

4. Transformed indolent B-cell NHL i. Any lymphoma otherwise eligible for Part 1 thathas transformed into a more aggressive lymphoma. Patients with transformation fromCLL or SLL (Richter's transformation) are not eligible for Part 1 CLL/SLL Cohorts:

5. CLL/SLL diagnosis that meets the International Workshop on Chronic LymphocyticLeukemia (IWCLL) criteria i. Disease characterized as Treatment Naive (TN) or R/Rdisease defined as disease that relapsed after, or was refractory to, at least 1prior therapy ii. Requiring treatment as defined by history MCL cohorts:

6. WHO-defined MCL i. R/R MCL defined as disease that relapsed after, or was refractoryto, at least 1 prior systemic therapy; ii. Requiring treatment in the opinion of theinvestigator

WM cohorts:

g. WHO-defined WM (clinical and definitive histologic diagnosis) i. R/R disease defined as disease that relapsed after, or was refractory to, at least 1 prior therapy; ii. Meeting at least 1 criterion for treatment according to consensus panel criteria from the Seventh International Workshop on Waldenström's Macroglobulinemia (Dimopoulos et al 2014)

• Measurable disease by computed tomography (CT)/magnetic resonance imaging (MRI),defined as:

1. CLL: at least 1 lymph node > 1.5 cm in longest diameter and measurable in 2perpendicular dimensions or clonal lymphocytes measured by flow cytometry

2. DLBCL, FL, MZL, MCL, or SLL: at least 1 lymph node > 1.5 cm in longest diameterOR 1 extranodal lesion > 1.0 cm in the longest diameter, measurable in at least 2 perpendicular dimensions. For MZL, isolated splenomegaly is consideredmeasurable for this study

3. WM: serum immunoglobulin (Ig) M level > 0.5 g/dL

• Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

• Adequate organ function

• Adequate pancreatic function indicated by:

1. Serum amylase ≤ 1.5 x upper limit of normal (ULN)

2. Serum lipase ≤ 1.5 x ULN

Key Exclusion Criteria:

• Known current central nervous system involvement by lymphoma/leukemia

• Known plasma cell neoplasm, prolymphocytic leukemia, history of or currentlysuspected Richter's syndrome

• Prior therapy ≥ 2 months with or progression on a B-cell lymphoma-2 (Bcl-2)inhibitor

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.