L-TIL in Patients With Malignancy Resistance to Anti-PD-1 Therapy

Inclusion Criteria:

• Expected lifespan is over 3 months

• malignant tumors diagnosed by pathological examination

• Imaging examination is at advanced stage with at least one measurable lesion

• Ineffective or resistant to previous anti-PD-1 therapy

• ECOG score 0-2

• Adequate organ function

• No other serious diseases that conflict with this protocol

• Women of childbearing age must check for a negative blood pregnancy test within 7days, and subjects of childbearing age must use appropriate contraception during thetest and within 3 months

• witten informed consent from the patients

Exclusion Criteria:

• Severe infectious disease within 4 weeks before enrollment

• Active hepatitis B or C virus or HIV infection

• Severe autoimmune disease or immunodeficiency disease

• Severe allergies

• Severe mental disorder

• Systematically used a large amount of glucocorticoids within 4 weeks before enrollment

• With severe heart, liver, kidney insufficiency, diabetes and other diseases

• Participation in other clinical studies in the past 3 months or having been treatedwith other gene products