A Study of Low and Standard-dose Ticagrelor After Intervention for ACS Patients

Last updated: December 6, 2023
Sponsor: Shanghai Tong Ren Hospital
Overall Status: Active - Recruiting

Phase

4

Condition

Chest Pain

Angina

Cardiac Disease

Treatment

Ticagrelor 60mg

Ticagrelor 90mg

Clinical Study ID

NCT04255602
HP2020125
  • Ages 18-90
  • All Genders

Study Summary

This study is to evaluate the safety and efficacy of 60mg ticagrelor plus 100mg Aspirin to prevent major adverse cardiovascular and cerebrovascular events in one years after drug-eluting stents implantation for Chinese ACS patients compared with 90mg ticagrelor plus 100mg Aspirin

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Subject must be at least 18 years of age
  2. Patients should have undergone successful percutaneous coronary intervention withdrug-eluting stent for acute coronary syndrome
  3. Subject understand the study requirements and the treatment procedures and providedinformed consent before the procedure

Exclusion

Exclusion Criteria:

  1. Female of childbearing potential, unless a recent pregnancy test is negative, whopossibly plan to become pregnant any time after enrollment into this study
  2. Active bleeding
  3. Known hypersensitivity or contraindication to study medications
  4. Non-cardiac co-morbid conditions are present with life expectancy <2 year or that mayresult in protocol non-compliance (per site investigator's medical judgment).
  5. Subjects with Cerebral hemorrhage history
  6. Subjects with stroke history in half a year
  7. subjects with malignant tumor
  8. subjects with whom oral anticoagulants are needed

Study Design

Total Participants: 2120
Treatment Group(s): 2
Primary Treatment: Ticagrelor 60mg
Phase: 4
Study Start date:
February 19, 2020
Estimated Completion Date:
December 31, 2024

Connect with a study center

  • The sixth people's hospital

    Shenzhen, Guangdong 200233
    China

    Site Not Available

  • Taishan people's hospital

    Taishan, Guangdong 529200
    China

    Active - Recruiting

  • The third people's hospital

    Xuzhou, Jiangshu 221005
    China

    Site Not Available

  • South East of Shandong hospital

    Liaocheng, Shandong
    China

    Active - Recruiting

  • Minhang hospital, Fudan University

    Shanghai, Shanghai 201100
    China

    Site Not Available

  • Songjiang hospital, Shanghai jiaotong university, school of medicine

    Shanghai, Shanghai
    China

    Site Not Available

  • shanghai Tongren hospital

    Shanghai, Shanghai 200050
    China

    Active - Recruiting

  • zhangshan hospital, Fudan University

    Shanghai, Shanghai 200032
    China

    Site Not Available

  • Ningbo 4th hospital

    Xiangshan, Zhejiang
    China

    Active - Recruiting

  • Yanzhou branch of affiliated hospital of Jining medical university

    Jining,
    China

    Site Not Available

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