Rifaximin in Patients With Diabetic Gastroparesis

Inclusion Criteria

• Men and women adult patients, aged 18-75, with diabetic gastroparesis

• Diagnosis of diabetic gastroparesis will have been made previously using a combination of symptoms (e.g., nausea, vomiting, bloating, early satiety, abdominal pain), the absence of mechanical obstruction, and delayed gastric emptying using a 4-hour, solid phase scintigraphic study (GES; > 20% remaining at 4 hours)

Exclusion Criteria

• Prior surgery to the stomach or esophagus

• Known mechanical obstruction of the GI tract

• Current or recent (< 4 weeks) use of opioids

• Current/active use of cannabis

• Current or recent (< 4 weeks) use of antibiotics

• Current or recent use of antifungal agents (< 4 weeks)

• Prior treatment with rifaximin (< 1 year)

• Uncontrolled diabetes with a HgbA1c > 12

• Severe uncontrolled or untreated anxiety or depression.