Identification of Biomarkers in Ischemic Stroke - Clinical Trial

Inclusion Criteria:

• For ischemic stroke :
• Age > 18-year-old
• Ischemic stroke diagnosed on clinical presentation and cerebral imaging (CT or MRIimaging)
• Inclusion inferior to 6 hours from stroke onset
• Initial NIHSS score > 0 at the time of clinical examination
• Patients with multimodal imaging either through MRI or CT perfusion and supra-aorticvessels and intra-cerebral vessels (Willis circle) imaging <0
• Procedure of signed consent in situation of emergency : consent of the patient if hehas the possibility to sign or his representative if he is present
• For hemorragic stroke :
• Age > 18 year-old
• Hemorrhagic stroke diagnosed on clinical presentation and cerebral imaging (CT or MRIimaging)
• Inclusion inferior to 6 hours from stroke onset
• Initial NIHSS score > 0 at the time of clinical examination
• Hemorrhagic patients are paired for age and sex with ischemic patients
• Procedure of signed consent in situation of emergency : consent of the patient if hehas the possibility to sign or his representative if he is present For healthy controls :
• Age > 18 year-old
• Stroke-free standardized questionnaire
• Initial NIHSS score = 0
• Rankin score = 0
• High risk cardiovascular subjects
• Controls are paired for age, sex and cardiovascular risk measured by a score (EuropeanHeart Score) with ischemic patients

Exclusion Criteria:

• Not affiliated to social security

• Patient under legal protection or deprived of liberty by a judicial or administrativedecision

• Patient whose follow-up will be impossible

• Prior stroke GROUP FOR ISCHEMIC STROKE :

• Patients with TIA and a negative cerebral CT or MRI GROUP FOR HEMORRAGIC STROKE :

• Cerebral hemorrhage related to subarachnoid hemorrhage

• Post-traumatic hemorrhage

• Hemorrhagic transformation in patients with ischemic stroke GROUP FOR HEALTHY CONTROLS :

• Contraindication MRI