Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity.

Inclusion Criteria:

• Male or female, age 18 years or older at the time of signing informed consent

• History of at least one self-reported unsuccessful dietary effort to lose bodyweight

For subjects without T2D at screening:

• Body mass index (BMI) of :

• greater than or equal to 30 kg/m^2

• greater than or equal to 27 kg/m^2 with the presence of at least one of thefollowing weight-related comorbidities (treated or untreated): hypertension,dyslipidaemia, obstructive sleep apnoea or cardiovascular disease

For subjects with T2D at screening:

• Diagnosed with T2D above or equal to 180 days prior to the day of screening

• Treated with either:

• diet and exercise alone or

• stable treatment (same drug(s), dose and dosing frequency) for at least 60 daysprior to the day of screening with up to 3 oral antidiabetic medications alone or inany combination (metformin, α-glucosidase inhibitor (AGI), SU, glinides, SGLT2i orglitazone) according to local label

• HbA1c 7.0-10.0% (53-86 mmol/mol) (both inclusive)

• BMI greater than or equal to 27 kg/m^2

Exclusion Criteria:

• A self-reported change in body weight above 5 kg (11 lbs) within 90 days beforescreening irrespective of medical records

For subjects without T2D at screening:

• HbA1c equal to or above 6.5% (48 mmol/mol) as measured by the central laboratory at screening

For subjects with T2D at screening :

• Renal impairment measured as estimated Glomerular Filtration Rate (eGFR) value ofbelow 30 mL/min/1.73 m^2 (below 60 mL/min/1.73 m^2 in subjects treated with SGLT2i)according to CKDEPI creatinine equation as defined by KDIGO 2012 by the centrallaboratory at screening

• Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verifiedby a fundus examination performed within the past 90 days prior to screening or inthe period between screening and randomisation. Pharmacological pupil-dilation is arequirement unless using a digital fundus photography camera specified fornon-dilated examination.