Appropriate Duration of Anti-Platelet and Thrombotic Strategy After 12 Months in Patients With Atrial Fibrillation Treated With Drug Eluting Stents

Phase

Condition

Arrhythmia

Chest Pain

Dysrhythmia

Treatment

NOAC monotherapy

Dual antithrombotic therapy with NOAC and clopidogrel

Dual therapy with apixaban and clopidogrel

Clinical Study ID

NCT04250116

4-2019-1128

Ages 19-85
All Genders

Study Summary

Atrial fibrillation patients with risk factors for stroke and systemic embolism require long-term anticoagulant therapy. Recently, non-vitamin K antagonist oral anticoagulant (NOAC) has shown their excellent safety and efficacy, and thus are widely accepted in clinical practice. Meanwhile, after percutaneous coronary intervention (PCI) using the drug-eluting stents due to coronary artery disease, the administration of one or more antiplatelets is essential to prevent the recurrence of stent thrombosis and myocardial infarction. Combined administration of anticoagulants and antiplatelets significantly lowers the incidence of ischemic events such as stroke and myocardial infarction, however, it also significantly increases the likelihood of bleeding leading to hospitalization, and or even death, thereby significantly affecting the clinical course of the AF patients who underwent PCI. Nevertheless, due to the very high mortality rate of stent thrombosis, the current standard of care guidelines recommend triple therapy with anticoagulants and double antiplatelet therapy (DAPT) in patients with atrial fibrillation for 1 month after coronary intervention, followed by co-administration of NOAC with single antiplatelet agent for 1 year. However, little is known after the optimal therapeutic strategy after 1 year. The purpose of this study is to compare the clinical results of single anticoagulant and clopidogrel combination therapy for maintenance therapy after 1 year in patients with atrial fibrillation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

over 19 years old
Patient who underwent PCI with DES more than 12 months ago
Non-valvular atrial fibrillation patients requiring long-term anticoagulation

Exclusion

Exclusion Criteria:

Over 85 years old
Pregnancy or Potential Pregnancy
Life expectancy within 1 year
Patients who refuse or do not understand the written consent form
Requiring anticoagulation due to history of mechanical valve replacement, mitralstenosis or deep vein thrombosis
Coagulopathy, continuous bleeding, or Hb level below 10 g/dL
Intracerebral hemorrhage within 2 months
Patients with gastrointestinal hemorrhage within three months of registration
Patients diagnosed with a gastrointestinal tumor that requires continuous treatment
Patients treated with 1st generation drug-eluting stents (Cypher, Taxus, or EndeavorSprint)

Study Design

NOAC monotherapy

April 28, 2020

April 30, 2026

Study Description

AF patients who had undergone PCI with DES implantation at least 12 months ago will be enrolled in this study. Decision for the antiplatelet agent discontinuation would be determined by randomization. Apixaban or Rivaroxaban would be prescribed to reduce the risk stroke or systemic embolism evoked by AF, and the administration of Warfarin, a vitamin-K dependent anticoagulant, would also be allowed according to attending physician's decision. The following criteria should be followed for the reduction of dosages according to the patient's renal function and other systemic conditions. Warfarin is administered to patients with creatinine clearance < 15 ml/min or dialysis. The drugs used in this study correspond to the international treatment guidelines after coronary intervention in patients with atrial fibrillation.NOAC and antiplatelet agents would be prescribed upon an outpatient visit. Clinical outcome would be followed for 2 years after study enrollment and randomization.

Screening

Baseline Serum AST/ALT level
Creatinine clearance (mL/min)
Concurrent administration of CYP3A4 agents: Ketoconazole, Itraconazole, Iopinavir/ritonavir, indinavir/ritonavir, conviaptan
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 @ Meeting 2 of 3 following criteria
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Serum creatinine level > 1.5 mg/dL
Body weight under 60 kg
age over 80 years old
eGFR from 15-49 mg/min

Connect with a study center

Severance Cardiovascular Hospital, Yonsei University Health System
Seoul,
Korea, Republic of
Site Not Available

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