The RESET Clinical Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Back Pain

Last updated: February 23, 2026
Sponsor: SPR Therapeutics, Inc.
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Chronic Pain

Treatment

SPRINT Peripheral Nerve Stimulation (PNS) System

Standard interventional management of low back pain

Clinical Study ID

NCT04246281
0151-CSP-000
CDMRP-PR170708
  • Ages 21-75
  • All Genders

Study Summary

The purpose of this study is to compare standard of care treatments for back pain to electrical stimulation. Stimulation is delivering small amounts of electricity to the nerves in your low back. This study will use a device called the SPRINT Peripheral Nerve Stimulation (PNS) System. The device is cleared by the FDA for up to 60 days of use for the relief of chronic or acute pain (including back pain)

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  • Chronic low back pain

Exclusion

Key Exclusion Criteria:

  • Body Mass Index (BMI) > 40

  • Prior lumbar surgery

  • Implanted electronic device

  • Pregnant

Study Design

Total Participants: 230
Treatment Group(s): 2
Primary Treatment: SPRINT Peripheral Nerve Stimulation (PNS) System
Phase:
Study Start date:
June 17, 2020
Estimated Completion Date:
April 30, 2027

Connect with a study center

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas 72205
    United States

    Site Not Available

  • University of Arkansas for Medical Sciences

    Little Rock 4119403, Arkansas 4099753 72205
    United States

    Site Not Available

  • IPM Medical Group

    Walnut Creek, California 94598
    United States

    Site Not Available

  • IPM Medical Group

    Walnut Creek 5406990, California 5332921 94598
    United States

    Site Not Available

  • Denver Back Pain Specialists

    Greenwood Village, Colorado 80111
    United States

    Site Not Available

  • Denver Back Pain Specialists

    Greenwood Village 5423908, Colorado 5417618 80111
    United States

    Site Not Available

  • International Spine, Pain & Performance Center

    Washington, District of Columbia 20006
    United States

    Site Not Available

  • International Spine, Pain & Performance Center

    Washington D.C. 4140963, District of Columbia 4138106 20006
    United States

    Site Not Available

  • Emory University

    Atlanta, Georgia 30329
    United States

    Site Not Available

  • Emory University

    Atlanta 4180439, Georgia 4197000 30329
    United States

    Site Not Available

  • Northwest Speciality Hospital

    Post Falls, Idaho 83854
    United States

    Site Not Available

  • Northwest Speciality Hospital

    Post Falls 5604353, Idaho 5596512 83854
    United States

    Site Not Available

  • Millennium Pain Center

    Bloomington, Illinois 61704
    United States

    Site Not Available

  • Millennium Pain Center

    Bloomington 4885164, Illinois 4896861 61704
    United States

    Site Not Available

  • Sinai Hospital of Baltimore

    Baltimore, Maryland 21215
    United States

    Site Not Available

  • Sinai Hospital of Baltimore

    Baltimore 4347778, Maryland 4361885 21215
    United States

    Site Not Available

  • Forest Health Medical Center

    Ypsilanti, Michigan 48198
    United States

    Site Not Available

  • Premier Pain Centers

    Shrewsbury, New Jersey 07702
    United States

    Site Not Available

  • Premier Pain Centers

    Shrewsbury 5104638, New Jersey 5101760 07702
    United States

    Site Not Available

  • Duke University

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Center for Clinical Research

    Winston-Salem, North Carolina 27103
    United States

    Site Not Available

  • Duke University

    Durham 4464368, North Carolina 4482348 27710
    United States

    Site Not Available

  • Center for Clinical Research

    Winston-Salem 4499612, North Carolina 4482348 27103
    United States

    Site Not Available

  • The Ohio State University

    Columbus, Ohio 43210
    United States

    Site Not Available

  • The Ohio State University

    Columbus 4509177, Ohio 5165418 43210
    United States

    Site Not Available

  • Main Line Spine

    King Of Prussia, Pennsylvania 19406
    United States

    Site Not Available

  • WellSpan Interventional Pain Specialists

    York, Pennsylvania 17402
    United States

    Site Not Available

  • Main Line Spine

    King of Prussia 5196220, Pennsylvania 6254927 19406
    United States

    Site Not Available

  • Carolinas Center for Advanced Management of Pain

    Greenville, South Carolina 29615
    United States

    Site Not Available

  • Institute of Precision Pain Medicine

    Corpus Christi, Texas 78414
    United States

    Site Not Available

  • Institute of Precision Pain Medicine

    Corpus Christi 4683416, Texas 4736286 78414
    United States

    Site Not Available

  • University of Utah

    Salt Lake City, Utah 84108
    United States

    Site Not Available

  • University of Utah

    Salt Lake City 5780993, Utah 5549030 84108
    United States

    Site Not Available

  • Hunter Holmes McGuire Veterans Affairs Medical Center

    Richmond, Virginia 23249
    United States

    Site Not Available

  • Virginia iSpine Physicians

    Richmond, Virginia 23235
    United States

    Site Not Available

  • Hunter Holmes McGuire Veterans Affairs Medical Center

    Richmond 4781708, Virginia 6254928 23249
    United States

    Site Not Available

  • Virginia iSpine Physicians

    Richmond 4781708, Virginia 6254928 23235
    United States

    Site Not Available

  • Spine and Nerve Center of St. Francis Hospital

    Charleston, West Virginia 25301
    United States

    Site Not Available

  • Spine and Nerve Center of St. Francis Hospital

    Charleston 4801859, West Virginia 4826850 25301
    United States

    Site Not Available

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