CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- a Descriptive Study

Last updated: December 20, 2023
Sponsor: Uppsala University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Fluxmed GrH will be used to measure the ventilation parameters

Clinical Study ID

NCT04237727
VENT001
  • Ages > 18
  • All Genders

Study Summary

The aim with this descriptive multicenter study is to examine the quality of the ventilation given by Emergency Medical Service (EMS) personnel during cardiopulmonary resuscitation (CPR).

Primary endpoint is the ventilation quality measured as ventilation frequency, tidal volume and minute ventilation.

This will primarily be studied during CPR with a 30 compression/2 ventilation ratio performed by the EMS personnel where the airway is managed with a supraglottic device but also in CPR with continuous ventilation (8-10 breaths/minute) after the airway management have been replaced with an endotracheal within the emergency room.

The inclusion of patients will be performed at two sites (Uppsala; Sweden and Utrecht; Holland), all out-of-hospital cardia arrest (OHCA) patients will receive care according to current CPR guidelines using mechanical chest compressions.

Eligibility Criteria

Inclusion

Inclusion Criteria: Out-of-hospital cardiac arrest (OHCA) treated with CPR performed by the EMS personnel

Exclusion

Exclusion Criteria:

  • Patient age < 18 years
  • Known pregnancy
  • Trauma related cardiac arrest (inc. hanging)

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: Fluxmed GrH will be used to measure the ventilation parameters
Phase:
Study Start date:
March 29, 2019
Estimated Completion Date:
December 30, 2024

Study Description

The inclusion is estimated to run over a two-year period to reach the goal of at least 200 patients. The study has been preceded by a trial period in an effort to solve any logistic and technical problems.

The study will be a prospective descriptive multicenter study where measurement of ventilation data will be sampled during CPR by EMS treating patients with OHCA. Any results from standard laboratory tests related to ventilation quality will be retracted from the patient medical journal systems. In addition to ventilatory variables measured as endpoints, secondary endpoints will also be outcome measures as any ROSC, survival and neurological outcome (mRS, GOS-E) measured at 30 days and at 6 months.

Connect with a study center

  • Regionale Ambulance Voorziening Utrecht, Netherlands

    Amersfoort, Utrecht
    Netherlands

    Active - Recruiting

  • Uppsala University hospital

    Uppsala, 75185
    Sweden

    Active - Recruiting

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