Efficacy and Safety of Angong Niuhuang Wan for Stroke

Inclusion Criteria:

1. Chinese adults aged 40 or above;
2. diagnosed as a stroke by a neurologist, with imaging of CT or MRI support;
3. Neurologist confirms the symptoms of stroke occur within 28 days and are clinicallystable. In the past 48 hours, the condition of the nervous system has not deterioratedsignificantly;
4. TCM diagnosis is a stroke and belongs to a heat syndrome;
5. There is a movement defect caused by stroke;
6. The severity of stroke was scored 5-25 by the National Institutes of Health BrainStroke Scale (NIHSS);
7. Informed consent will be given by participant or its representatives

Exclusion Criteria:

1. The movement defects are not associated with stroke. Before commencement of studytreatment, patient has physical activity dysfunction caused by lameness ,osteoarthritis, rheumatoid arthritis, gouty arthritis, etc. that may affectneurological function examination;
2. Subjects are unlikely to come back for follow-up visits during the 24-week studyperiod;
3. The subject has a brain tumor on a computed tomography scan (CT);
4. The subject has thrombocytopenia (known platelet count <100,000 / mm3) or coagulopathydisease;
5. Taking warfarin or other anticoagulant;
6. Concomitant diseases such as severe hypertension or diabetes;
7. Comorbidities or complications associated with drug evaluation;
8. Pregnant or breast-feeding female.
9. The alanine aminotransferase (ALT) value is 1.5 times higher than the normal maximumvalue in liver function test and the estimated glomerular filtration rate (eGFR) <30ml/min/1.73 m2 in the renal function test.
10. Present the sign of pure yin syndrome or yin / yang defecation in TCM diagnosis;
11. Subject has G6PD
12. Known swallowing problem
13. Dependent in all daily life activities