RASCALS: Rapid Assay for Sick Children With Acute Lung Infection Study

Last updated: October 12, 2021
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Overall Status: Active - Recruiting

Phase

N/A

Condition

Bronchitis (Pediatric)

Bronchitis

Respiratory Syncytial Virus (Rsv) Infection

Treatment

N/A

Clinical Study ID

NCT04233268
277039
  • Ages < 16
  • All Genders

Study Summary

Lower Respiratory Tract infections are a common cause of admission to the intensive care unit. Children routinely receive antibiotics until the tests confirm whether the infection is bacterial or viral. The exclusion of bacterial infection may take 48 hours or longer for culture tests on biological samples to be completed. In many cases, the results may be inconclusive or negative if the patient has already received antibiotics prior to the sample being taken.

A rapid assay to detect the most likely cause of infection could improve the speed with which antibiotic therapy is rationalised or curtailed.

This study aims to assess whether a new genetic testing kit which can identify the presence of bacteria and viruses within hours rather than days is a feasible tool in improving antibiotic prescribing and rationalisation of therapy in critically ill children with suspected lower respiratory tract infection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Aged >37 weeks corrected gestation and ≤16 years old
  2. Receiving mechanical ventilation
  3. Commencing or already receiving antibiotic treatment for lower respiratory tractinfection

Exclusion

Exclusion Criteria:

  1. Survival not expected/active medical treatment expected to be withdrawn/palliative careonly

Study Design

Total Participants: 250
Study Start date:
June 06, 2020
Estimated Completion Date:
February 28, 2025

Connect with a study center

  • Addenbrooke's Hospital

    Cambridge, Cambs CB2 9NS
    United Kingdom

    Active - Recruiting

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