Southeast Asian Brugada Syndrome Cohort

Last updated: January 14, 2020
Sponsor: Chulalongkorn University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Arrhythmia

Treatment

N/A

Clinical Study ID

NCT04232787
2558-114
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Brugada syndrome (BrS) is the leading cause of sudden death in young Asian adults including Thailand. This syndrome may be hereditary and involve mutations in certain genes. Aim of the study is to identify the relationship between genetic variants and the diagnosis/clinical severity of patients with BrS.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Thai nationality

  • The patient has at least one of confirmed Brugada type 1 ECG in at least one of rightprecordial leads (v1 or v2) with or without pharmacologic provocative testing. Theconfirmed ECG is standard 12 lead ECG or Brugada lead

Exclusion

Exclusion Criteria:

  • The patient has other cardiac diseases such as ischemic heart disease, valvular heartdisease, congenital heart disease, myocarditis and pericarditis

  • The patient has type 2 or type 3 Brugada ECG without type 1 ECG during pharmacologicprovocative testing and/or Brugada lead

  • The patient had one time of Brugada type 1 ECG during drug use without reproducibility

Study Design

Total Participants: 750
Study Start date:
January 28, 2016
Estimated Completion Date:
January 31, 2023

Study Description

This cohort study recruits BrS patients with confirmed Brugada type 1 ECG and healthy volunteers in Thailand. Data collection consists of demographic, clinical data, ECG and blood sample for genetic studies. Genotyping was done by whole genome sequencing and SNP array then compared between cases and controls. Each BrS patient will be followed up prospectively for symptoms and AICD shock. Subsequently, the study will analyze relationship between genetic variants and clinical data against clinical severity of BrS patients.

Connect with a study center

  • Siriraj Hospital, Mahidol University

    Bangkok Noi, Bangkok 10700
    Thailand

    Active - Recruiting

  • Vajira Hospital

    Dusit, Bangkok 10300
    Thailand

    Active - Recruiting

  • Chulalongkorn University

    Pathum Wan, Bangkok 10330
    Thailand

    Active - Recruiting

  • Faculty of Medicine Ramathibodi Hospital, Mahidol University

    Ratchathewi, Bangkok 10400
    Thailand

    Active - Recruiting

  • Bhumibol Adulyadej RTAF Hospital

    Sai Mai, Bangkok 10220
    Thailand

    Active - Recruiting

  • Bumrungrad International Hospital

    Watthana, Bangkok 10110
    Thailand

    Active - Recruiting

  • Pacific Rim Electrophysiology Research Institute Data Coordinating Center

    Watthana, Bangkok 10110
    Thailand

    Active - Recruiting

  • Bangkok Hospital

    Bangkok, 10310
    Thailand

    Active - Recruiting

  • Faculty of Medicine, Chiang Mai University

    Chiang Mai, 50200
    Thailand

    Active - Recruiting

  • Queen Sirikit Heart Center of the Northeast

    Khon Kaen, 40002
    Thailand

    Active - Recruiting

  • Central Chest Hospital

    Nonthaburi, 11000
    Thailand

    Active - Recruiting

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