Phase
Condition
N/ATreatment
N/AClinical Study ID
Ages 18-70 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age between 18 and 70 years
Diagnosis of Parkinson's Disease; as defined by the United Kingdom Parkinson's DiseaseSociety Brain Bank (UKPDSBB) criteria
Patients eligible for subthalamic bilateral deep brain stimulation (STN-DBS) accordingto local inclusion criteria;
Freezing of gait in the OFF-dopa condition with item 2.13 of the MDS-UPDRS > 0 inusual life;
Patient having read and understood the information letter and signed the InformedConsent Form
Patient affiliated with, or beneficiary of a social security category
Stability of others medical disorders or that do not interfere with the researchprotocol.
Woman of childbearing potential with effective contraception according to WHOdefinition (estrogen-progestin or intra-uterine device or tubal ligation) since atleast 3 months (negative urinary pregnancy test at inclusion)
Exclusion
Exclusion Criteria:
Actual and severe psychiatric pathology or other neurological disorder
Dementia (MMS <24/30)
Contraindication to research MRI (without contrast product) such as claustrophobia,metallic splinters in the eyes, ferromagnetic foreign bodies close to nervestructures, cardiac, ORL and neurological devices not MRI compatible, wearing ofosteosynthseis equipment prior to 1980, metal prostheses, bypass valvesventriculoperitoneal neurosurgery, tattoos containing iron particles…
Contraindication to surgery: hemostasis trouble, anticoagulants or antiagregantstreatment, ongoing infection
Hypersensitivity to contrasts agents
Persons under guardianship, tutorship or any other administrative or judicial measureof deprivation of rights and liberty
Subject at the time of exclusion from other biomedical research or participating inany other biomedical research or therapeutic trial
Pregnant or parturient or lactating woman or lack of proven and effectivecontraception according to WHO definition (estrogen-progestin or intra-uterine deviceor tubal ligation) (for women of childbearing age)
Study Design
Connect with a study center
CHU de ROUEN
Rouen, 76000
FranceActive - Recruiting
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