Phase
Condition
Tourette's Syndrome
Mood Disorders
Psychosis
Treatment
N/AClinical Study ID
Ages 18-65 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Patients - Inclusion Criteria:
Primary diagnosis of schizophrenia or schizoaffective disorder
Clinically stable (discretion of psychiatrist)
Consistent history of AVHs over the course of illness
>3 AVHs per week
Positive and Negative Syndrome Scale (PANSS) score of >3
Primary medications limited to one of the atypical antipsychotics (medicationsstabilized for 4 weeks prior to enrollment)
Exclusion
Patients - Exclusion Criteria:
Experiencing an acute psychotic episode
Current drug/alcohol dependence
Significant medical illness & mental retardation/learning disability
Extra-pyramidal symptoms resulting in disordered movement
Abnormal audiometric assessment (thresholds for pure tones >25 dB)
History of significant neurological issues & head injuries/concussions resulting inloss of consciousness for >5 minutes Healthy Controls - Inclusion Criteria:
In good physical health
No history of serious mental health issues Healthy Controls - Exclusion Criteria:
Personal history of psychiatric disorder
Family history of schizophrenia in first degree relatives & history of mental healthissues in first degree relatives that required extensive treatment or hospitalization
Current/history of substance abuse
Significant medical illness
Extra-pyramidal symptoms resulting in movement disorder
Abnormal audiometric assessment (thresholds for pure tones >25 dB)
Significant neurological issues & head injuries/concussions resulting in loss ofconsciousness for >5 minutes
Study Design
Connect with a study center
Royal Ottawa Mental Health Centre
Ottawa, Ontario K1Z7K4
CanadaActive - Recruiting
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