KDIGO Bundle to Prevent AKI in Sepsis

Last updated: July 27, 2020
Sponsor: Hospital General Universitario Elche
Overall Status: Active - Recruiting

Phase

N/A

Condition

Renal Failure

Kidney Failure

Kidney Disease

Treatment

N/A

Clinical Study ID

NCT04222361
PI 42/2018
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Summary: Controlled, prospective, randomized and randomized clinical trial of two intervention groups (standard care vs. preventive recommendations the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for AKI) of patients diagnosed with sepsis and abdominal post-surgical septic shock with positive results in the risk determination of acute renal injury by NephroCheck® Test that integrates the urinary biomarkers TIMP-2 and IGFBP-7.

Hypothesis: The implementation of a package of preventive measures proposed by the KDIGO guide can reduce the occurrence and severity of acute renal injury in the high-risk abdominal post-surgical septic patient detected by urinary biomarkers for early detection.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients older than 18 years.

  • Patients (or their informed family members) who accept and sign the informed consent.

  • Patients diagnosed with sepsis or abdominal post-surgical septic shock.

Exclusion

Exclusion Criteria:

  • Patients under 18 years.

  • Patients (or their authorized relatives) who refuse to sign the informed consent.

  • Patients diagnosed with sepsis or non-surgical septic shock.

  • Patients diagnosed with sepsis or septic shock of origin other than abdominal.

  • Patients with AKI stages KDIGO 2 and 3 and / or renal replacement therapy.

  • Patients with chronic renal failure and glomerular filtration <30 ml / min and / orundergoing treatment with dialysis or previous renal transplantation.

  • Patients with AKI of origin other than the diagnosed septic, such asglomerulonephritis or interstitial nephritis, renal artery occlusion and / orpostrenal obstruction.

Study Design

Total Participants: 100
Study Start date:
October 01, 2020
Estimated Completion Date:
November 30, 2022

Connect with a study center

  • Surgical Intensive Care Unit of the General University Hospital of Elche

    Elche, Alicante 03203
    Spain

    Active - Recruiting

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