Intrapapillary Botulinum Toxin Injection for PREvention of Post-surgical PAncREactic Fistula

Last updated: July 7, 2023
Sponsor: Assistance Publique - Hôpitaux de Paris
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pancreatic Disorders

Treatment

botulinum toxin injection

Clinical Study ID

NCT04220931
P170913J
  • Ages > 18
  • All Genders

Study Summary

Surgery is required for the treatment of many pancreatic conditions, either malignant or benign. Mortality of pancreatic surgery can be up to 3% even in expert centers. Morbidity is high, postoperative pancreatic fistula (POPF) being the main postoperative complication. In its current definition (drain output of any measurable fluid >= postoperative day 3 with amylase content >3 times the serum amylase activity and with clinical consequence), the incidence of postoperative PF is between 15 and 30 %. Most POPF resolve spontaneously but when refractory POPF occurs, it may lead to severe complications. POPF severity is graded as follows: grade B in case of change in medical management: infection without organ failure, specific medication (total parenteral nutrition, somatostatin analogs, antibiotics), persistent drainage > 3 weeks, angiographic procedure for bleeding, prolonged hospital stay; grade C in case of reoperation or PF-related organ failure or death.

No specific prophylactic treatment of POPF is currently recommended by clinical guidelines. In clinical research, many prophylactic strategies have been attempted with partial efficacy. Endoscopic pancreatic sphincterotomy with plastic stent placement is effective in pre-and postoperative management of pancreatic fistula but with the need of a highly competent interventional endoscopist. Intrapapillary botulinum toxin injection is believed to induce relaxation of the pancreatic sphincter, leading to a " pharmacological " pancreatic sphincterotomy without any morbidity.

A recent phase I/II prospective study has shown promising results in this indication, with no clinically relevant pancreatic fistula when botulinum toxin was injected. Based on this observation we hypothesize that intrapapillary botulinum toxin injection during an endoscopic procedure before surgery could be effective for the prevention of post-surgical pancreatic fistula

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with scheduled distal pancreatectomy for any indication: open or laparoscopicdistal pancreatectomy with or without splenectomy
  • Age ≥ 18years

Exclusion

Exclusion Criteria:

  • History of myasthenia gravis or Eaton-Lambert syndrome
  • Inflammatory myositis <2 years or preexisting motor neuron disease or neuropathies
  • ASA score > III
  • Pregnancy or lactation
  • Altered anatomy of the duodenum and/or the major papilla (prior surgery, priorendoscopic sphincterotomy)
  • Scheduled pancreaticoduodenectomy (Whipple procedure)
  • Scheduled total pancreatectomy
  • Scheduled central pancreatectomy
  • Scheduled pancreatic enucleation
  • Calcified chronic pancreatitis (suspected on preoperative cross-sectional imaging)
  • Pancreas divisum (suspected on preoperative cross-sectional imaging)
  • Toxin botulinum contraindications (hypersensitivity to albumin or to saccharose,infection or inflammation at the injection site concerned, generalized muscleweakness)
  • Preoperative administration of somatostatin analogs: for long-acting somatostatinanalogs, a 1-month washout period is necessary; for short-acting somatostatin analogs,a 24-hours washout period is necessary
  • Any kind of surgical method to reinforce the pancreatic stump:
  • Use of a bioabsorbable patch
  • Use of fibrin glue
  • Use of a ligament patch
  • Tutorship, trusteeship
  • Concurrent participation in other experimental trials
  • Not Affiliation to the French social security
  • Not Ability to give their consent and not written informed consent
  • Distal pancreatectomy extended to neighbouring organs (except spleen and gallbladder)or to the vessels (celiac axis, portal vein) Secondary exclusion criteria: patients who did not have the planned surgery in less than 4weeks after the botulinum toxin injection.

Study Design

Total Participants: 460
Treatment Group(s): 1
Primary Treatment: botulinum toxin injection
Phase:
Study Start date:
March 27, 2023
Estimated Completion Date:
March 01, 2027

Study Description

Surgery is required for the treatment of many pancreatic conditions, either malignant or benign. Mortality of pancreatic surgery can be up to 3% even in expert centers. Morbidity is high, postoperative pancreatic fistula (POPF) being the main postoperative complication. In its current definition (drain output of any measurable fluid >= postoperative day 3 with amylase content >3 times the serum amylase activity and with clinical consequence), the incidence of postoperative PF is between 15 and 30 %. Most POPF resolve spontaneously but when refractory POPF occurs, it may lead to severe complications. POPF severity is graded as follows: grade B in case of change in medical management: infection without organ failure, specific medication (total parenteral nutrition, somatostatin analogs, antibiotics), persistent drainage > 3 weeks, angiographic procedure for bleeding, prolonged hospital stay; grade C in case of reoperation or PF-related organ failure or death.

No specific prophylactic treatment of POPF is currently recommended by clinical guidelines. In clinical research, many prophylactic strategies have been attempted with partial efficacy. Endoscopic pancreatic sphincterotomy with plastic stent placement is effective in pre-and postoperative management of pancreatic fistula but with the need of a highly competent interventional endoscopist. Intrapapillary botulinum toxin injection is believed to induce relaxation of the pancreatic sphincter, leading to a " pharmacological " pancreatic sphincterotomy without any morbidity.

A recent phase I/II prospective study has shown promising results in this indication, with no clinically relevant pancreatic fistula when botulinum toxin was injected. Based on this observation we hypothesize that intrapapillary botulinum toxin injection during an endoscopic procedure before surgery could be effective for the prevention of post-surgical pancreatic fistula

This study will be a prospective, multicentric, phase III, superiority, controlled, randomized (1:1), open-label, clinical trial with two parallel arms (intrapapillary botulinum toxin versus standard care), using a PROBE (Prospective Randomized Open Blinded End-point) methodology.

Patients with scheduled distal pancreatectomy for any indication

Sources of funding for the trial : French Ministry supports this study by PHRC-N 2017.

The botulinum toxin provides by MERZ France (producer of Xeomin)

Connect with a study center

  • PRAT

    Clichy, 92110
    France

    Active - Recruiting

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