A Comparison Between Ivor-Lewis and McKeown Minimally Invasive Esophagectomy

Last updated: November 14, 2022
Sponsor: The Second Hospital of Shandong University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Esophageal Cancer

Treatment

N/A

Clinical Study ID

NCT04217239
MIE ZYP2
  • Ages 30-80
  • All Genders

Study Summary

Surgery is still the main treatment for esophageal cancer, however, the complication and mortality rate of open esophagectomy is high. As a result, the thoracoscopic- laparoscopic minimally invasive esophagectomy (MIE) was developed. The MIE mainly comprised two surgical approaches:

MIE McKeown approach (cervical anastomosis) and MIE Ivor-Lewis approach (intrathoracicanastomosis). The MIE with intrathoracic anastomosis (Ivor-Lewis) is increasingly used for the treatment of mid and lower esophageal cancers. Our study is trying to compare the safety, feasibility, and short-term and long- term outcomes between MIE Ivor-Lewis approach and MIE McKeown approach for the treatment of lower thoracic esophageal cancer and esophageal- gastric junction.

Eligibility Criteria

Inclusion

Inclusion Criteria:

(I) Patients with clinically staged T1-3N0-2M0 tumors; good cardiopulmonary function;

(II) Patients with lower thoracic esophageal tumors and esophageal- gastric junction tumor;

(III) Patients without a previous history of cancer;

(IV) Patients without a previous history of neck or chest surgery;

Exclusion

Exclusion Criteria:

(I) cardiopulmonary function not good enough for surgery;

(II) Patients with hybrid MIE

Study Design

Total Participants: 200
Study Start date:
January 01, 2020
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • Yunpeng Zhao

    Jinan, Shandong 250033
    China

    Active - Recruiting

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