Thrombus Aspiration in STEMI Patients With High Thrombus Burden

Last updated: November 14, 2024
Sponsor: Guangdong Provincial People's Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Thrombosis

Myocardial Ischemia

Occlusions

Treatment

Thrombus aspiration

PCI Alone

Clinical Study ID

NCT04212494
GDREC2018404H(R2)
  • Ages > 18
  • All Genders

Study Summary

This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade ≥3) are included. Patients are randomized to be treated with or without manual thrombus aspiration(TA) during primary percutaneous coronary intervention(PPCI) by a ratio of 1:1.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age ≥ 18 years;

  2. STEMI patients undergoing primary PCI within 12 hours after the onset of symptoms;

  3. High thrombus burden after guidewire passes the lesion (TIMI thrombus grade ≥3);

  4. Informed consent must be voluntary;

Exclusion

Exclusion Criteria:

  1. Haemodynamic instability or cardiogenic shock;

  2. After thrombolytic therapy;

  3. The predicted survival time is less than 6 months due to non-cardiac disease;

  4. History of coronary artery bypass grafting;

  5. Participate in other researches within 30 days;

  6. Preoperative gastrointestinal bleeding or contraindications to dual antiplatelettherapy;

  7. Patients were considered unsuitable by other researchers.

Study Design

Total Participants: 3838
Treatment Group(s): 2
Primary Treatment: Thrombus aspiration
Phase:
Study Start date:
August 30, 2020
Estimated Completion Date:
February 28, 2026

Study Description

This study is intended to explore the efficacy of thrombus aspiration (TA) in ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden who received primary PCI within 12 hours after the onset of symptoms, reducing the incidence of cardiovascular death, recurrent myocardial infarction, stent thrombosis, target vessel revascularization within 180 days or stroke in 30 days.

Connect with a study center

  • Fujian Provincial Hospital

    Fuzhou, Fujian 350001
    China

    Site Not Available

  • First People's Hospital of Foshan

    Foshan, Guangdong 528000
    China

    Site Not Available

  • First People's Hospital of Shunde (Affiliated Hospital at Shunde, Southern Medical University)

    Foshan, Guangdong 528300
    China

    Site Not Available

  • The Second People's Hospital of Nanhai District

    Foshan, Guangdong 528251
    China

    Active - Recruiting

  • Guangdong Provincial Hospital of traditional Chinese Medicine

    Guangzhou, Guangdong 510120
    China

    Site Not Available

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong 510000
    China

    Site Not Available

  • Guangzhou General Hospital of Guangzhou Military Command

    Guangzhou, Guangdong 510010
    China

    Site Not Available

  • Guangzhou Panyu Central Hospital

    Guangzhou, Guangdong 510000
    China

    Site Not Available

  • Huadu District People's Hospital of Guangzhou

    Guangzhou, Guangdong 510800
    China

    Site Not Available

  • Huangpu Division of The First Affiliated Hospital, Sun Yat-sen University

    Guangzhou, Guangdong 510700
    China

    Site Not Available

  • Nanfang Hospital

    Guangzhou, Guangdong 510515
    China

    Site Not Available

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong 510120
    China

    Site Not Available

  • The Second Affiliated Hospital, Sun Yat-Sen University

    Guangzhou, Guangdong 510235
    China

    Site Not Available

  • The first Affiliated Hospital, Sun Yat-Sen University

    Guangzhou, Guangdong 510080
    China

    Site Not Available

  • Zhujiang Hospital of Southern Medical University

    Guangzhou, Guangdong 510280
    China

    Site Not Available

  • Huizhou Third People's Hospital

    Huizhou, Guangdong 516002
    China

    Site Not Available

  • Jiangmen Central Hospital

    Jiangmen, Guangdong 529030
    China

    Site Not Available

  • Kaiping Central Hospital

    Kaiping, Guangdong 529300
    China

    Active - Recruiting

  • Maoming People's Hospital

    Maoming, Guangdong 525000
    China

    Site Not Available

  • Nanxiong people's Hospital

    Nanxiong, Guangdong 512400
    China

    Site Not Available

  • The Second Affiliated Hospital of Shantou university Medical College

    Shantou, Guangdong 515041
    China

    Active - Recruiting

  • Yue Bei People's Hospital

    Shaoguan, Guangdong 512026
    China

    Site Not Available

  • Peking University Shenzhen Hospital

    Shenzhen, Guangdong 518035
    China

    Site Not Available

  • Shenzhen Bao'an District People's Hospital

    Shenzhen, Guangdong 518101
    China

    Site Not Available

  • Shenzhen People's Hospital

    Shenzhen, Guangdong 518020
    China

    Site Not Available

  • The Eighth Affiliated Hospital, Sun Yat-Sen University

    Shenzhen, Guangdong 518033
    China

    Site Not Available

  • Taishan people's Hospital

    Taishan, Guangdong 529200
    China

    Site Not Available

  • People's Hospital of Yangjiang City

    Yangjiang, Guangdong 529500
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Guangdong Medical University

    Zhanjiang, Guangdong
    China

    Site Not Available

  • Sihui people's Hospital

    Zhaoqing, Guangdong 526200
    China

    Active - Recruiting

  • Zhongshan People's Hospital

    Zhongshan, Guangdong 528403
    China

    Site Not Available

  • The Fifth Affiliated Hospital, Sun Yat-Sen University

    Zhuhai, Guangdong 519000
    China

    Site Not Available

  • Zhuhai people's Hospital

    Zhuhai, Guangdong 519000
    China

    Site Not Available

  • Guilin people's Hospital

    Guilin, Guangxi 541002
    China

    Site Not Available

  • Hainan People's Hospital

    Haikou, Hainan 570311
    China

    Site Not Available

  • The Second Clinical College of Hainan Medical University

    Haikou, Hainan 460106
    China

    Site Not Available

  • Wuhan Asia Heart Hospital

    Wuhan, Hubei 430022
    China

    Site Not Available

  • The Second Xiangya Hospital of Central South University

    Changsha, Hunan 410008
    China

    Site Not Available

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan 13787318063
    China

    Site Not Available

  • GanZhou Municopal Hospital

    Ganzhou, Jiangxi 341000
    China

    Site Not Available

  • Shangyou Hospital

    Ganzhou, Jiangxi 341200
    China

    Site Not Available

  • Affiliated Hospital, Weifang Medical University

    Weifang, Shandong 261031
    China

    Site Not Available

  • The first Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shanxi 710061
    China

    Site Not Available

  • Sichuan Provincial People's Hospital

    Chengdu, Sichuan 610072
    China

    Site Not Available

  • West China Hospital

    Chengdu, Sichuan 610041
    China

    Site Not Available

  • Kashgar first people's Hospital

    Kashgar, Xinjiang 844000
    China

    Site Not Available

  • The First Affilicated Hospital of Xinjiang Medical University

    Urumqi, Xinjiang 830054
    China

    Site Not Available

  • Yan'an Hospital of Kunming City

    Kunming, Yunnan 65005
    China

    Site Not Available

  • Shaoxing people's Hospital

    Shaoxing, Zhejiang 312000
    China

    Site Not Available

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang 325000
    China

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.