The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery

Last updated: March 24, 2020
Sponsor: Yonsei University
Overall Status: Active - Recruiting

Phase

4

Condition

Kidney Failure

Renal Failure

Kidney Disease

Treatment

N/A

Clinical Study ID

NCT04210453
4-2019-1051
  • Ages > 20
  • All Genders

Study Summary

In cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin C concentration is sharply decreased. The anti-inflammatory and anti-oxidant effects of vitamin C and the effects of reducing vasoconstrictor use have been demonstrated in patients with sepsis and septic shock, however, the foregoing effects have not been validated in patients undergoing cardiac surgery.

In this study, investigators investigate the effect of intravenous vitamin C on the incidence of acute renal injury after valvular heart surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients older than 20 years and undergoing elective valvular heart surgery whosepreoperative acute renal failure score is ≥3 (moderate to severe risk).

Exclusion

Exclusion Criteria:

  • Emergency operation

  • Cardiogenic shock or ventricular-assist device (eg. ECMO, IABP)

  • Severe chronic kidney disease (GFR(CKD-EPI) <30ml/min/1.73m2)

  • Patients with past history of gout or renal stone or hyperoxaluria or cystinuria

  • Hemolytic anemia due to pyruvate kinase deficiency or glucose-6-phosphatedehydrogenase deficiency

  • Sicklemia or thalassemia

  • Hemochromatosis

  • Allergy to disodium ethylenediamine-tetraacetate or ascorbic acid

  • Patients taking aspirin up to 3 days before surgery

  • Patients taking antiepileptic drug or fluphenazine or steroid

  • Patients taking vitamin C within a month of surgery

  • Pregnant or lactating women

  • Patients who cannot understand the informed consent (eg. Foreigner)

Study Design

Total Participants: 264
Study Start date:
March 24, 2020
Estimated Completion Date:
December 31, 2022

Connect with a study center

  • Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research Institute, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine

    Seoul,
    Korea, Republic of

    Active - Recruiting

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