A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

Inclusion Criteria:

• Participants who may benefit from study participation in the opinion of theinvestigator and participated in a prior nemolizumab study for PN including: (a).Participants who completed the treatment period in a phase 3 pivotal study (NCT04501666 or NCT04501679) and enroll within 56 days OR (b). Participants who werepreviously randomized in the nemolizumab phase 2a PN study (NCT03181503) OR (c).Participants who completed through Week 24 of the phase 3b durability study (NCT05052983) or who exit the study due to relapse may be eligible to re-enter inthe LTE study within 28 days of exiting the durability study (selected countries/selected sites)

• Female participants of childbearing potential (that is, fertile, following menarcheand until becoming post-menopausal unless permanently sterile) must agree either tobe strictly abstinent throughout the study and for 12 weeks after the last studydrug injection, or to use an adequate and approved method of contraceptionthroughout the study and for 12 weeks after the last study drug injection

• Participant willing and able to comply with all of the time commitments andprocedural requirements of the clinical study protocol, including periodic weeklyrecordings by the participant using an electronic handheld device provided for thisstudy

• Understand and sign an informed consent form (ICF) before any investigationalprocedure(s) are performed

Exclusion Criteria:

• Participants who, during their participation in a prior nemolizumab study,experienced an adverse event (AE) which in the opinion of the investigator couldindicate that continued treatment with nemolizumab may present an unreasonable riskfor the participant

• Body weight < 30 kg

• Pregnant women (positive pregnancy test result at screening or baseline visit orre-entry Week R0 visit), breastfeeding women, or women planning a pregnancy duringthe clinical study

• Any medical or psychological condition that may put the participant at significantrisk according to the investigator's judgment, if he/she participates in theclinical study, or may interfere with study assessments (example, poor venous accessor needle-phobia)

• Planning or expected to have a major surgical procedure during the clinical study

• Participants unwilling to refrain from using prohibited medications during theclinical study

• History of alcohol or substance abuse within 6 months prior to the screening visitor re-entry Week R0 visit