Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

Last updated: February 17, 2026
Sponsor: Alexion Pharmaceuticals, Inc.
Overall Status: Active - Recruiting

Phase

N/A

Condition

Polymyositis (Inflammatory Muscle Disease)

Neuropathy

Myasthenia Gravis Generalised

Treatment

N/A

Clinical Study ID

NCT04202341
ALXN-MG-501
  • Ages > 18
  • All Genders

Study Summary

Long-term, multicenter, multinational, observational, registry of patients with gMG that is designed to collect data on clinical outcomes and safety in patients prescribed Alexion C5 inhibitor therapies (C5IT) such as eculizumab (Soliris®) and ravulizumab (Ultomiris®).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Participants with a diagnosis of gMG who are treated with Alexion C5IT at the timeof enrollment, including patients previously treated with Soliris or Ultomiris andwithdrawn from treatment.

  2. Capable of giving signed informed consent, which includes compliance with theprotocol requirements and restrictions.

  3. Participants must have myasthenia gravis historical data, such as MG-ADL and MGFAclass, available to be enrolled in the Registry.

Exclusion

Exclusion Criteria:

  1. Participants currently enrolled in an Alexion-sponsored interventional clinical study for treatment of gMG cannot be enrolled in the Alexion gMG Registry while enrolled/participating in the clinical study for gMG therapy.

Study Design

Total Participants: 500
Study Start date:
December 02, 2019
Estimated Completion Date:
October 01, 2029

Study Description

At the time of enrollment in the Registry, participant records will be queried for retrospective information about the participants' medical history and gMG disease treatment history. Following enrollment, prospective data collection will be performed using data obtained as part of the routine clinical care and through patient-reported outcome methods in use. Data will be collected using an electronic data capture system. The duration of data collection for the Registry will be up to 5 years from the day of enrollment.

Connect with a study center

  • Clinical Trial Site

    Vienna, 1090
    Austria

    Site Not Available

  • Clinical Trial Site

    Vienna 2761369, 1090
    Austria

    Active - Recruiting

  • Clinical Trial Site

    Brampton, Ontario L6R 3J7
    Canada

    Site Not Available

  • Clinical Trial Site

    London, Ontario N6A 5A5
    Canada

    Site Not Available

  • Clinical Trial Site

    Brampton 5907364, Ontario 6093943 L6R 3J7
    Canada

    Active - Recruiting

  • Clinical Trial Site

    London 6058560, Ontario 6093943 N6A 5A5
    Canada

    Active - Recruiting

  • Clinical Trial Site

    Montreal, Quebec H2X 3E4
    Canada

    Site Not Available

  • Clinical Trial Site

    Montreal 6077243, Quebec 6115047 H2X 3E4
    Canada

    Active - Recruiting

  • Clinical Trial Site

    Chengdu, Sichuan 610041
    China

    Site Not Available

  • Clinical Trial Site

    Beijing 1816670, 100730
    China

    Active - Recruiting

  • Clinical Trial Site

    Changchun 2038180, 130021
    China

    Active - Recruiting

  • Clinical Trial Site

    Chengdu 1815286, 610072
    China

    Active - Recruiting

  • Clinical Trial Site

    Guangzhou 1809858, 510080
    China

    Active - Recruiting

  • Clinical Trial Site

    Jinan 1805753, 250021
    China

    Active - Recruiting

  • Clinical Trial Site

    Nanchang 1800163, 330006
    China

    Active - Recruiting

  • Clinical Trial Site

    Qingdao 1797929, 266003
    China

    Active - Recruiting

  • Clinical Trial Site

    Shijiazhuang 1795270, 050000
    China

    Active - Recruiting

  • Clinical Trial Site

    Hanover, Hannover 30625
    Germany

    Site Not Available

  • Clinical Trial Site

    Hanover 2910831, Hannover 30625
    Germany

    Active - Recruiting

  • Clinical Trial Site

    Milan 6951411, 20133
    Italy

    Active - Recruiting

  • Clinical Trial Site

    Milano, 20133
    Italy

    Site Not Available

  • Clinical Trial Site

    Naples, 80138
    Italy

    Site Not Available

  • Clinical Trial Site

    Naples 3172394, 80138
    Italy

    Active - Recruiting

  • Clinical Trial Site

    Abhā 110690, 62523
    Saudi Arabia

    Active - Recruiting

  • Clinical Trial Site

    Jeddah 105343, 22384
    Saudi Arabia

    Active - Recruiting

  • Clinical Trial Site

    Riyadh 108410, 14611
    Saudi Arabia

    Active - Recruiting

  • Clinical Trial Site

    Birmingham, Alabama 35294
    United States

    Site Not Available

  • Clinical Trial Site

    Birmingham 4049979, Alabama 4829764 35294
    United States

    Active - Recruiting

  • Clinical Trial Site

    Phoenix, Arizona 85001
    United States

    Site Not Available

  • Clinical Trial Site

    Scottsdale, Arizona 85251
    United States

    Site Not Available

  • Clinical Trial Site

    Scottsdale 5313457, Arizona 5551752 85251
    United States

    Active - Recruiting

  • Clinical Trial Site

    Fresno, California 93710
    United States

    Site Not Available

  • Clinical Trial Site

    Orange, California 92868
    United States

    Site Not Available

  • Clinical Trial Site

    Rancho Mirage, California 92270
    United States

    Site Not Available

  • Clinical Trial Site

    Sylmar, California 91342
    United States

    Site Not Available

  • Clinical Trial Site

    Fresno 5350937, California 5332921 93710
    United States

    Active - Recruiting

  • Clinical Trial Site

    Orange 5379513, California 5332921 92868
    United States

    Active - Recruiting

  • Clinical Trial Site

    Rancho Mirage 5386015, California 5332921 92270
    United States

    Active - Recruiting

  • Clinical Trial Site

    Sylmar 5400784, California 5332921 91342
    United States

    Active - Recruiting

  • Clinical Trial Site

    Colorado Springs, Colorado 80907
    United States

    Site Not Available

  • Clinical Trial Site

    Fort Collins, Colorado 80528
    United States

    Site Not Available

  • Clinical Trial Site

    Colorado Springs 5417598, Colorado 5417618 80907
    United States

    Active - Recruiting

  • Clinical Trial Site

    Fort Collins 5577147, Colorado 5417618 80528
    United States

    Active - Recruiting

  • Clinical Trial Site

    New Haven, Connecticut 06520
    United States

    Site Not Available

  • Clinical Trial Site

    New Haven 4839366, Connecticut 4831725 06520
    United States

    Active - Recruiting

  • Clinical Trial Site

    Washington, District of Columbia 10010
    United States

    Site Not Available

  • Clinical Trial Site

    Washington D.C. 4140963, District of Columbia 4138106 10010
    United States

    Active - Recruiting

  • Clinical Trial Site

    Clearwater, Florida 33761
    United States

    Site Not Available

  • Clincal Trial Site

    Gainesville, Florida 32608
    United States

    Site Not Available

  • Clinical Trial Site

    Jacksonville, Florida 32209
    United States

    Site Not Available

  • Clinical Trial Site

    Tampa, Florida 33612
    United States

    Site Not Available

  • Clinical Trial Site

    Clearwater 4151316, Florida 4155751 33761
    United States

    Active - Recruiting

  • Clincal Trial Site

    Gainesville 4156404, Florida 4155751 32608
    United States

    Active - Recruiting

  • Clinical Trial Site

    Jacksonville 4160021, Florida 4155751 32209
    United States

    Active - Recruiting

  • Clinical Trial Site

    Tampa 4174757, Florida 4155751 33612
    United States

    Active - Recruiting

  • Clinical Trial Site

    Augusta, Georgia 30912
    United States

    Site Not Available

  • Clinical Trial Site

    Augusta 4180531, Georgia 4197000 30912
    United States

    Active - Recruiting

  • Clinical Trial Site

    Lake Barrington, Illinois 60010
    United States

    Site Not Available

  • Clinical Trial Site

    Rolling Meadows, Illinois 60008
    United States

    Site Not Available

  • Clinical Trial Site

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • Clinical Trial Site

    Iowa City 4862034, Iowa 4862182 52242
    United States

    Active - Recruiting

  • Clinical Trial Site

    Lexington, Kentucky 40503
    United States

    Site Not Available

  • Clinical Trial Site

    Lexington 4297983, Kentucky 6254925 40503
    United States

    Active - Recruiting

  • Clinical Trial Site

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Clinical Trial Site

    Boston 4930956, Massachusetts 6254926 02215
    United States

    Active - Recruiting

  • Clinical Trial Site

    Lansing, Michigan 48824
    United States

    Site Not Available

  • Clinical Trial Site

    Lansing 4998830, Michigan 5001836 48824
    United States

    Active - Recruiting

  • Clinical Trial Site

    Columbia, Missouri 65212
    United States

    Site Not Available

  • Clinical Trial Site

    Columbia 4381982, Missouri 4398678 65212
    United States

    Active - Recruiting

  • Clinical Trial Site

    Las Vegas, Nevada 89145
    United States

    Site Not Available

  • Clinical Trial Site

    New Hyde Park, New York 11042
    United States

    Site Not Available

  • Clinical Trial Site

    New Hyde Park 5128514, New York 5128638 11042
    United States

    Active - Recruiting

  • Clinical Trial Site

    Chapel Hill, North Carolina 27599
    United States

    Site Not Available

  • Clinical Trial Site

    Charlotte, North Carolina 28207
    United States

    Site Not Available

  • Clinical Trial Site

    Durham, North Carolina 27705
    United States

    Site Not Available

  • Clinical Trial Site

    Chapel Hill 4460162, North Carolina 4482348 27599
    United States

    Active - Recruiting

  • Clinical Trial Site

    Charlotte 4460243, North Carolina 4482348 28207
    United States

    Active - Recruiting

  • Clinical Trial Site

    Durham 4464368, North Carolina 4482348 27705
    United States

    Active - Recruiting

  • Clinical Trial Site

    Dayton, Ohio 45459
    United States

    Site Not Available

  • Clinical Trial Site

    Dayton 4509884, Ohio 5165418 45459
    United States

    Active - Recruiting

  • Clinical Trial Site

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Clinical Trial Site

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Active - Recruiting

  • Clinical Trial Site

    Chattanooga, Tennessee 37403
    United States

    Site Not Available

  • Clinical Trial Site

    Knoxville, Tennessee 37920
    United States

    Site Not Available

  • Clinical Trial Site

    Chattanooga 4612862, Tennessee 4662168 37403
    United States

    Active - Recruiting

  • Clinical Trial Site

    Knoxville 4634946, Tennessee 4662168 37920
    United States

    Active - Recruiting

  • Clinical Trial Site

    Dallas, Texas 75206
    United States

    Site Not Available

  • Clinical Trial Site

    Houston, Texas 77030
    United States

    Site Not Available

  • Clinical Trial Site

    Dallas 4684888, Texas 4736286 75206
    United States

    Active - Recruiting

  • Clinical Trial Site

    Houston 4699066, Texas 4736286 77030
    United States

    Active - Recruiting

  • Clinical Trial Site

    Burlington, Vermont 05401
    United States

    Site Not Available

  • Clinical Trial Site

    Burlington 5234372, Vermont 5242283 05401
    United States

    Active - Recruiting

  • Clinical Trial Site

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

  • Clinical Trial Site

    Milwaukee 5263045, Wisconsin 5279468 53215
    United States

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.