Exercise Training to Improve PTSD Symptoms and Health in Older Veterans

Last updated: March 17, 2025
Sponsor: VA Office of Research and Development
Overall Status: Completed

Phase

N/A

Condition

Anxiety Disorders

Post-traumatic Stress Disorders

Panic Disorders

Treatment

Healthy Aging Attention Control (HA-ATC)

Exercise Training

Clinical Study ID

NCT04199182
E3120-R
RX003120
  • Ages > 65
  • All Genders

Study Summary

Posttraumatic stress disorder (PTSD) is prevalent among military Veterans and is more than just a psychological condition; PTSD has profound negative impacts on health, function, and quality of life. Older Veterans are the largest patient population served by the Veterans Health Administration (VHA), and many have lived with PTSD for 40+ years. Veterans with PTSD engage in low levels of physical activity and spend much of their time in sedentary activities, adding to their risk of physical disability. The benefits of exercise on mental health and physical well-being in older adults are well-substantiated, but the effects of exercise training on late-life PTSD symptoms is a new area of study. This study is designed to examine the effects of 6 months of supervised exercise training on PTSD symptoms and PTSD-related conditions (e.g., functional impairment, sleep) in 188 older Veterans with PTSD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Veteran status

  • registered for care at Durham VA Health Care System (VAHCS)

  • live within 50 miles of fitness facility

  • meet diagnostic criteria for PTSD as assessed by the CAPS-5

Exclusion

Exclusion Criteria:

  • history of any psychiatric disorder with severe psychotic features in the past 5years (e.g., bipolar disorder, mania), as indicated by ICD-10 codes F20-F29 (ICD-9category 298.9)

  • prominent suicidal ideation or hospitalization for suicidality in the previous 6months

  • clinically significant: neurological disorder, systemic illness affecting centralnervous system (CNS) function, or history of seizure disorder in the past 5 years

  • uncontrolled diabetes defined as:

  • Abnormal fasting plasma glucose 126 mg/dL, random plasma glucose 200 mg/dL

  • no active medications for diabetes management (Metformin, insulin, etc.)

  • no clinical notes in the patient's electronic health record (EHR) indicatingmonitoring by primary care physician (PCP) or Endo for diabetes management)

  • end stage liver disease or currently receiving dialysis

  • physical disabilities precluding use of exercise equipment (assistive mobilitydevices acceptable)

  • significant cognitive impairment or diagnosis of Alzheimer's Disease orDementia

  • hospitalization or ER visit in the past 6 months for conditions contraindicatedfor exercise (cardiac event; physical trauma)

Study Design

Total Participants: 80
Treatment Group(s): 2
Primary Treatment: Healthy Aging Attention Control (HA-ATC)
Phase:
Study Start date:
June 07, 2021
Estimated Completion Date:
February 28, 2025

Connect with a study center

  • Durham VA Medical Center, Durham, NC

    Durham, North Carolina 27705-3875
    United States

    Site Not Available

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