Efficacy and Safety of Pembrolizumab (MK-3475) Plus Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) (MK-3475-991/KEYNOTE-991)

Last updated: January 31, 2025
Sponsor: Merck Sharp & Dohme LLC
Overall Status: Active - Not Recruiting

Phase

3

Condition

Urologic Cancer

Prostate Cancer, Early, Recurrent

Allergy

Treatment

Enzalutamide

Androgen Deprivation Therapy (ADT)

Placebo

Clinical Study ID

NCT04191096
3475-991
2019-003633-41
MK-3475-991
KEYNOTE-991
jRCT2080225171
2080225171
205267
  • Ages > 18
  • Male

Study Summary

This study will assess the efficacy and safety of pembrolizumab plus enzalutamide plus Androgen Deprivation Therapy (ADT) versus placebo plus enzalutamide plus ADT in participants with mHSPC. The primary hypothesis is that in participants with mHSPC, the combination of pembrolizumab plus enzalutamide plus ADT is superior to placebo plus enzalutamide plus ADT with respect to 1) radiographic progression-free survival (rPFS) per Prostate Cancer Working Group (PCWG)-modified Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by blinded independent central review (BICR) and 2) overall survival (OS). As of 19-JAN-2023, the study was unblinded and all study participants stopped ongoing treatment with pembrolizumab/placebo and will continue to receive Standard of Care treatment until meeting protocol-specified discontinuation criteria if deriving clinical benefit. Safety analysis will be performed at the end of the study; there will be no further analyses for efficacy and electronic patient-reported outcome (ePRO) endpoints collected from participants beyond the IA1 cutoff date. All study participants will stop ongoing treatment with pembrolizumab/placebo. Exceptions may be requested for study participants who, in the assessment of their study physician, are benefitting from the combination of enzalutamide and pembrolizumab, after consulting with the Sponsor. All other study participants should be discontinued from study and be offered standard of care (SOC) treatment as deemed necessary by the Investigator. If enzalutamide as SOC is not accessible off study to the participant, central sourcing may continue. As of Amendment 04, disease progression will no longer be centrally verified, participants will only be assessed locally. As of Amendment 4, Second Course treatment is not an option for participants. There are currently no participants in the Second Course Phase.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male participants with histologically- or cytologically-confirmed adenocarcinoma ofthe prostate without small cell histology

  • Has metastatic disease assessed by investigator and verified by BICR by either ≥2bone lesions on bone scan and/or visceral disease by computed tomography/magneticresonance imaging (CT/MRI)

  • Willing to maintain continuous Androgen Deprivation Therapy (ADT) with aluteinizing-hormone releasing hormone (LHRH) agonists or antagonists during studytreatment or have a history of bilateral orchiectomy

  • Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1assessed within 10 days of randomization

  • Participants receiving bone resorptive therapy (including, but not limited to,bisphosphonate or denosumab) must have been on stable doses prior to randomization

  • Has adequate organ function

  • Has provided newly obtained core or excisional biopsy (obtained within 12 months ofscreening) from soft tissue not previously irradiated (samples from tumorsprogressing in a prior site of radiation are allowed). Participants with bone onlyor bone predominant disease may provide a bone biopsy sample

  • Male participants must agree to the following during the intervention period and forat least 120 days after the last dose of study intervention: Refrain from donatingsperm PLUS either be abstinent from heterosexual intercourse and agree to remainabstinent OR agree to use contraception, unless confirmed to be azoospermic

  • Male participants must agree to use male condom when engaging in any activity thatallows for passage of ejaculate to another person of any sex

Exclusion

Exclusion Criteria:

  • Has a known additional malignancy that is progressing or has required activetreatment in the last 3 years

  • Has an active autoimmune disease that has required systemic treatment in past 2years

  • Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy

  • Has undergone major surgery including local prostate intervention (excludingprostate biopsy) within 28 days prior to randomization and not recovered adequatelyfrom the toxicities and/or complications

  • Has a gastrointestinal disorder affecting absorption or is unable to swallowtablets/capsules

  • Has an active infection (including tuberculosis) requiring systemic therapy

  • Has a history of (non-infectious) pneumonitis that required steroids or has currentpneumonitis

  • Has known active human immunodeficiency virus (HIV), hepatitis B virus (HBV) orhepatitis C virus (HCV) infection

  • Has known or suspected central nervous system (CNS) metastases and/or carcinomatousmeningitis

  • Has a history of seizure or any condition that may predispose to seizure

  • Has a history of loss of consciousness within 12 months of screening

  • Has had myocardial infarction or uncontrolled angina within 6 months prior torandomization, or has New York Heart Association class III or IV congestive heartfailure or a history of New York Heart Association class III or IV congestive heartfailure

  • Has hypotension (systolic blood pressure <86 millimeters of mercury [mmHg]) oruncontrolled hypertension (systolic blood pressure >170 mmHg or diastolic bloodpressure >105 mmHg) at the screening visit

  • Has a history of clinically significant ventricular arrhythmias

  • Has hypersensitivity to pembrolizumab and/or enzalutamide and/or any of theirexcipients

  • Has received prior ADT as neoadjuvant/adjuvant therapy for non-metastatic prostatecancer for >39 months in duration or within 9 months prior to randomization or withevidence of disease progression while receiving ADT

  • Has had prior treatment with a next generation hormonal agent (eg, abiraterone,enzalutamide, apalutamide, darolutamide)

  • Has received prior therapy with an anti-programmed cell death-1 (anti-PD-1),anti-programmed cell death-ligand 1 (anti-PD-L1), or anti-programmed celldeath-ligand 2 (anti PD-L2) agent or with an agent directed to another stimulatoryor coinhibitory T-cell receptor

  • Has received a live vaccine within 30 days prior to randomization

  • Has a "superscan" bone scan

  • Has had an allogenic tissue/solid organ transplant

  • Is expecting to conceive or father children within the projected duration of thestudy, starting with the screening visit through 120 days after the last dose ofstudy treatment

  • Has received any prior pharmacotherapy, radiation therapy or surgery for metastaticprostate cancer with the following exceptions:

  1. Up to 3 months of ADT or orchiectomy with or without concurrentfirst-generation antiandrogens, if patient was not treated with docetaxel

  2. May have 1 course of palliative radiation or surgical therapy to treat symptomsresulting from metastatic disease if it was administered at least 4 weeks priorto randomization

  3. For participants with low volume metastatic disease, may have 1 course ofdefinitive radiotherapy if it was administered at least 4 weeks prior torandomization

  4. Up to 6 cycles of docetaxel therapy with final treatment administrationcompleted within 2 months of randomization and no evidence of diseaseprogression. In these participants up to 6 months of ADT permitted

Study Design

Total Participants: 1251
Treatment Group(s): 5
Primary Treatment: Enzalutamide
Phase: 3
Study Start date:
February 12, 2020
Estimated Completion Date:
December 03, 2025

Connect with a study center

  • Chris OBrien Lifehouse ( Site 0300)

    Camperdown, New South Wales 2050
    Australia

    Site Not Available

  • Port Macquarie Base Hospital ( Site 0301)

    Port Macquarie, New South Wales 2444
    Australia

    Site Not Available

  • Riverina Cancer Care Center ( Site 0302)

    Wagga Wagga, New South Wales 2650
    Australia

    Site Not Available

  • Gallipoli Medical Research Foundation ( Site 0309)

    Greenslopes, Queensland 4120
    Australia

    Site Not Available

  • John Flynn Hospital & Medical Centre ( Site 0308)

    Tugun, Queensland 4224
    Australia

    Site Not Available

  • Box Hill Hospital ( Site 0304)

    Box Hill, Victoria 3128
    Australia

    Site Not Available

  • Monash Health ( Site 0305)

    Clayton, Victoria 3168
    Australia

    Site Not Available

  • Peter MacCallum Cancer Centre ( Site 0306)

    Melbourne, Victoria 3000
    Australia

    Site Not Available

  • Fiona Stanley Hospital ( Site 0311)

    Murdoch, Western Australia 6150
    Australia

    Site Not Available

  • Ordensklinikum Linz GmbH Elisabethinen ( Site 0901)

    Linz, Oberosterreich 4020
    Austria

    Site Not Available

  • Landeskrankenhaus Salzburg - Universitatklinikum der PMU ( Site 0900)

    Salzburg, 5020
    Austria

    Site Not Available

  • Krankenhaus der Barmherzigen Brüder Wien ( Site 0904)

    Wien, 1020
    Austria

    Site Not Available

  • Medizinische Universitaet Wien ( Site 0903)

    Wien, 1090
    Austria

    Site Not Available

  • Oncocentro Ceara ( Site 2309)

    Fortaleza, Ceara 60135-237
    Brazil

    Site Not Available

  • Instituto de Cancer e Transplante de Curitiba ICTR ( Site 2306)

    Curitiba, Parana 80510-130
    Brazil

    Site Not Available

  • Hospital Sao Vicente de Paulo ( Site 2303)

    Passo Fundo, Rio Grande Do Sul 99010-080
    Brazil

    Site Not Available

  • Hospital de Clinicas de Porto Alegre ( Site 2304)

    Porto Alegre, Rio Grande Do Sul 90035-903
    Brazil

    Site Not Available

  • Clinica de Oncologia Reichow ( Site 2308)

    Blumenau, Santa Catarina 89010-340
    Brazil

    Site Not Available

  • Fundacao Dr Amaral Carvalho ( Site 2302)

    Jau, Sao Paulo 17210-120
    Brazil

    Site Not Available

  • Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 2305)

    Sao Paulo, 01246-000
    Brazil

    Site Not Available

  • The Ottawa Hospital ( Site 0100)

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

  • Niagara Health System - St. Catharines ( Site 0107)

    St. Catharines, Ontario L2S 0A9
    Canada

    Site Not Available

  • CISSS de la Monteregie-Centre ( Site 0105)

    Greenfield Park, Quebec J4V 2H1
    Canada

    Site Not Available

  • CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0106)

    Montreal, Quebec H3T 1M5
    Canada

    Site Not Available

  • Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0109)

    Montreal, Quebec H2X 3E4
    Canada

    Site Not Available

  • CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0101)

    Quebec, G1R 2J6
    Canada

    Site Not Available

  • Centro Investigación del Cáncer James Lind ( Site 2401)

    Temuco, Araucania 4780000
    Chile

    Site Not Available

  • IC La Serena Research ( Site 2406)

    La Serena, Coquimbo 1720430
    Chile

    Site Not Available

  • Clinica Universidad Catolica del Maule ( Site 2407)

    Talca, Maule 3465584
    Chile

    Site Not Available

  • Clinica Alemana ( Site 2408)

    Santiago, Region M. De Santiago 7650568
    Chile

    Site Not Available

  • Pontificia Universidad Catolica de Chile ( Site 2402)

    Santiago, Region M. De Santiago 8330032
    Chile

    Site Not Available

  • Sociedad Medica Aren y Bachero Limitada ( Site 2403)

    Santiago, Region M. De Santiago 8420383
    Chile

    Site Not Available

  • Oncocentro ( Site 2400)

    Vina del Mar, Valparaiso 2520598
    Chile

    Site Not Available

  • Peking University First Hospital ( Site 0800)

    Beijing, Beijing 100034
    China

    Site Not Available

  • Zhejiang Provincial People's Hospital ( Site 0809)

    Hangzhou, Zhejiang 310014
    China

    Site Not Available

  • The First Affiliated Hospital of Wenzhou Medical University ( Site 0834)

    Wenzhou, Zhejiang 325000
    China

    Site Not Available

  • Institucion Prestadora de Servicios de Salud Clinica de la Costa LTDA ( Site 2504)

    Barranquilla, Atlantico 080020
    Colombia

    Site Not Available

  • Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 2509)

    Valledupar, Cesar 200001
    Colombia

    Site Not Available

  • Administradora Country SA - Clinica del Country ( Site 2507)

    Bogota, Distrito Capital De Bogota 110221
    Colombia

    Site Not Available

  • Instituto Nacional de Cancerologia E.S.E ( Site 2506)

    Bogota, Distrito Capital De Bogota 110321
    Colombia

    Site Not Available

  • Hemato Oncologos ( Site 2503)

    Cali, Valle Del Cauca 760042
    Colombia

    Site Not Available

  • Rigshospitalet ( Site 1005)

    Copenhagen, Hovedstaden 2100
    Denmark

    Site Not Available

  • Herlev og Gentofte Hospital. ( Site 1004)

    Herlev, Hovedstaden 2730
    Denmark

    Site Not Available

  • Aalborg Universitetshospital ( Site 1000)

    Aalborg, Nordjylland 9000
    Denmark

    Site Not Available

  • Odense Universitetshospital ( Site 1003)

    Odense, Syddanmark 5000
    Denmark

    Site Not Available

  • Vejle Sygehus ( Site 1002)

    Vejle, Syddanmark 7100
    Denmark

    Site Not Available

  • Keski-Suomen keskussairaala ( Site 1017)

    Jyvaskyla, Mellersta Finland 40620
    Finland

    Site Not Available

  • Tampereen yliopistollinen sairaala ( Site 1022)

    Tampere, Pirkanmaa 33520
    Finland

    Site Not Available

  • HYKS ( Site 1020)

    Helsinki, Varsinais-Suomi 00290
    Finland

    Site Not Available

  • TYKS T-sairaala Syopatautien pkl ( Site 1019)

    Turku, Varsinais-Suomi 20521
    Finland

    Site Not Available

  • Keski-Suomen keskussairaala ( Site 1017)

    Jyväskylä, 40620
    Finland

    Site Not Available

  • Centre Leon-Berard ( Site 1110)

    Lyon, Auvergne 69373
    France

    Site Not Available

  • Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1114)

    Strasbourg, Bas-Rhin 67200
    France

    Site Not Available

  • CHU de Brest -Site Hopital Morvan ( Site 1103)

    Brest, Bretagne 29200
    France

    Site Not Available

  • Centre Georges Francois Leclerc ( Site 1112)

    Dijon, Cote-d Or 21079
    France

    Site Not Available

  • CHU-Jean Minjoz ( Site 1101)

    Besancon, Doubs 25000
    France

    Site Not Available

  • Institut Bergonie ( Site 1104)

    Bordeaux, Gironde 33076
    France

    Site Not Available

  • Hopital Foch ( Site 1105)

    Suresnes, Hauts-de-Seine 92151
    France

    Site Not Available

  • C.H.R.U. de Rennes. Hopital de Pontchaillou ( Site 1117)

    Rennes, Ille-et-Vilaine 35033
    France

    Site Not Available

  • Institut Jean Godinot-Clinical Research Unit ( Site 1118)

    Reims, Marne 51726
    France

    Site Not Available

  • Centre D Oncologie de Gentilly ( Site 1107)

    Nancy, Meurthe-et-Moselle 54100
    France

    Site Not Available

  • Centre Bourgogne ( Site 1119)

    Lille, Nord-Pas-de-Calais 59000
    France

    Site Not Available

  • Hospices Civils de Lyon Centre Hospitalier Lyon Sud ( Site 1102)

    Pierre Benite, Rhone 69310
    France

    Site Not Available

  • Hopital Henri Mondor ( Site 1116)

    Creteil, Val-de-Marne 94010
    France

    Site Not Available

  • Universitaetsklinikum Freiburg ( Site 1200)

    Freiburg, Baden-Wurttemberg 79106
    Germany

    Site Not Available

  • Klinikum der Universitaet Muenchen - Grosshadern ( Site 1210)

    Muenchen, Bayern 81377
    Germany

    Site Not Available

  • Klinikum Rechts der Isar ( Site 1206)

    Munchen, Bayern 81675
    Germany

    Site Not Available

  • Klinikum Nuernberg Nord ( Site 1213)

    Nurnberg, Bayern 90419
    Germany

    Site Not Available

  • Staedtisches Klinikum Braunschweig gGmbH ( Site 1217)

    Braunschweig, Niedersachsen 38126
    Germany

    Site Not Available

  • Universitaetsklinikum der Technischen Universitaet Dresden ( Site 1204)

    Dresden, Sachsen 01307
    Germany

    Site Not Available

  • Universitaetsklinikum Magdeburg A.o.R. ( Site 1211)

    Magdeburg, Sachsen-Anhalt 39120
    Germany

    Site Not Available

  • Charite Universitaetsmedizin Berlin ( Site 1201)

    Berlin, 10117
    Germany

    Site Not Available

  • Universitaetsklinikum Hamburg-Eppendorf ( Site 1212)

    Hamburg, 20246
    Germany

    Site Not Available

  • Cork University Hospital ( Site 1304)

    Cork, T12 DC4A
    Ireland

    Site Not Available

  • Beaumont Hospital ( Site 1302)

    Dublin, 00009
    Ireland

    Site Not Available

  • St Vincents University Hospital ( Site 1300)

    Dublin, DO4 YN63
    Ireland

    Site Not Available

  • Tallaght University Hospital ( Site 1301)

    Dublin, D24 NR0A
    Ireland

    Site Not Available

  • University Hospital Limerick ( Site 1305)

    Limerick, V94 F858
    Ireland

    Site Not Available

  • University Hospital Waterford ( Site 1303)

    Waterford, X91 ER8E
    Ireland

    Site Not Available

  • Rambam Medical Center ( Site 1400)

    Afula, 1834111
    Israel

    Site Not Available

  • Rambam Medical Center ( Site 1400)

    Haifa, 3109601
    Israel

    Site Not Available

  • Hadassah Ein Kerem Medical Center ( Site 1404)

    Jerusalem, 9112001
    Israel

    Site Not Available

  • Meir Medical Center ( Site 1401)

    Kfar Saba, 4428164
    Israel

    Site Not Available

  • Rabin Medical Center ( Site 1402)

    Petach Tikva, 4941492
    Israel

    Site Not Available

  • Sourasky Medical Center ( Site 1403)

    Tel Aviv, 6423906
    Israel

    Site Not Available

  • Assaf Harofeh Medical Center ( Site 1405)

    Zerifin, 70300
    Israel

    Site Not Available

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 1503)

    Meldola, Emilia-Romagna 47014
    Italy

    Site Not Available

  • Istituto Clinico Humanitas Research Hospital ( Site 1500)

    Rozzano, Lombardia 20089
    Italy

    Site Not Available

  • Centro Di Riferimento Oncologico ( Site 1511)

    Aviano, Pordenone 33081
    Italy

    Site Not Available

  • IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 1509)

    Bari, 70124
    Italy

    Site Not Available

  • Azienda Ospedaliera Cannizzaro ( Site 1501)

    Catania, 95126
    Italy

    Site Not Available

  • Istituto Nazionale dei Tumori ( Site 1510)

    Milano, 20133
    Italy

    Site Not Available

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1508)

    Napoli, 80131
    Italy

    Site Not Available

  • Fondazione Policlinico Universitario A. Gemelli ( Site 1512)

    Roma, 00168
    Italy

    Site Not Available

  • Azienda Ospedaliera Santa Maria ( Site 1502)

    Terni, 05100
    Italy

    Site Not Available

  • A.O. Verona-Ospedale Civile Maggiore Borgo-Trento ( Site 1504)

    Verona, 37126
    Italy

    Site Not Available

  • Toho University Sakura Medical Center ( Site 0732)

    Sakura, Chiba 285-8741
    Japan

    Site Not Available

  • Ehime University Hospital ( Site 0745)

    Toon, Ehime 791-0295
    Japan

    Site Not Available

  • Sapporo Medical University Hospital ( Site 0730)

    Sapporo, Hokkaido 060-8543
    Japan

    Site Not Available

  • Kitasato University Hospital ( Site 0734)

    Sagamihara, Kanagawa 252-0375
    Japan

    Site Not Available

  • Yokohama City University Medical Center ( Site 0735)

    Yokohama, Kanagawa 232-0024
    Japan

    Site Not Available

  • Nara Medical University Hospital ( Site 0744)

    Kashihara, Nara 634-8522
    Japan

    Site Not Available

  • Kindai University Hospital ( Site 0743)

    Osakasayama, Osaka 589-8511
    Japan

    Site Not Available

  • Osaka University Hospital ( Site 0742)

    Suita, Osaka 565-0871
    Japan

    Site Not Available

  • Saitama Medical University International Medical Center ( Site 0737)

    Hidaka, Saitama 350-1298
    Japan

    Site Not Available

  • Dokkyo Medical University Saitama Medical Center ( Site 0736)

    Koshigaya, Saitama 343-8555
    Japan

    Site Not Available

  • Hamamatsu University Hospital ( Site 0748)

    Hamamatsu, Shizuoka 431-3192
    Japan

    Site Not Available

  • Yamaguchi University Hospital ( Site 0746)

    Ube, Yamaguchi 755-8505
    Japan

    Site Not Available

  • Chiba Cancer Center ( Site 0733)

    Chiba, 260-8717
    Japan

    Site Not Available

  • Harasanshin Hospital ( Site 0747)

    Fukuoka, 812-0033
    Japan

    Site Not Available

  • Nagano Municipal Hospital ( Site 0731)

    Nagano, 381-8551
    Japan

    Site Not Available

  • Osaka City University Hospital ( Site 0741)

    Osaka, 545-8586
    Japan

    Site Not Available

  • Nippon Medical School Hospital ( Site 0738)

    Tokyo, 113-8603
    Japan

    Site Not Available

  • Tokyo Women's Medical University Hospital ( Site 0739)

    Tokyo, 162-8666
    Japan

    Site Not Available

  • Toranomon Hospital ( Site 0740)

    Tokyo, 105-8470
    Japan

    Site Not Available

  • Chonnam National University Hwasun Hospital ( Site 0406)

    Jeollanam-do, Jeonranamdo 58128
    Korea, Republic of

    Site Not Available

  • National Cancer Center ( Site 0400)

    Gyeonggi-do, Kyonggi-do 10408
    Korea, Republic of

    Site Not Available

  • Seoul National University Bundang Hospital ( Site 0401)

    Seongnam-si, Kyonggi-do 13620
    Korea, Republic of

    Site Not Available

  • Kyungpook National University Chilgok Hospital ( Site 0404)

    Daegu, Taegu-Kwangyokshi 41404
    Korea, Republic of

    Site Not Available

  • Asan Medical Center ( Site 0403)

    Seoul, 05505
    Korea, Republic of

    Site Not Available

  • Seoul National University Hospital ( Site 0405)

    Seoul, 03080
    Korea, Republic of

    Site Not Available

  • Severance Hospital Yonsei University Health System ( Site 0402)

    Seoul, 03722
    Korea, Republic of

    Site Not Available

  • Hospital San Lucas Cardiologica del Sureste ( Site 2606)

    Tuxtla Gutierrez, Chiapas 29090
    Mexico

    Site Not Available

  • Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 2607)

    Guadalajara, Jalisco 44280
    Mexico

    Site Not Available

  • Centro Estatal de Cancerologia de Chihuahua ( Site 2608)

    Chihuahua, 31000
    Mexico

    Site Not Available

  • Centro Oncologico Internacional. SEDNA ( Site 2609)

    Mexico City, 04700
    Mexico

    Site Not Available

  • Grupo Medico Camino SC ( Site 2613)

    Mexico City, 03310
    Mexico

    Site Not Available

  • Boca Raton Clinical Research QTO ( Site 2611)

    Queretaro, 76070
    Mexico

    Site Not Available

  • Radboud University Medical Center ( Site 1606)

    Nijmegen, Gelderland 6500 HB
    Netherlands

    Site Not Available

  • Antoni van Leeuwenhoek Ziekenhuis ( Site 1603)

    Amsterdam, Noord-Holland 1066 CX
    Netherlands

    Site Not Available

  • Vrije Universiteit Medisch Centrum ( Site 1601)

    Amsterdam, Noord-Holland 1081 HV
    Netherlands

    Site Not Available

  • Isala Klinieken, Locatie Sophia ( Site 1604)

    Zwolle, Overijssel 8025 AB
    Netherlands

    Site Not Available

  • Meander Medisch Centrum ( Site 1602)

    Amersfoort, Utrecht 3813 TZ
    Netherlands

    Site Not Available

  • Franciscus Gasthuis en Vlietland ( Site 1605)

    Schiedam, Zuid-Holland 3118 JH
    Netherlands

    Site Not Available

  • St. Antonius Ziekenhuis ( Site 1600)

    Utrecht, 3543 AZ
    Netherlands

    Site Not Available

  • Auckland City Hospital ( Site 0321)

    Auckland, 1023
    New Zealand

    Site Not Available

  • Hospital Nacional Carlos Alberto Seguin Escobedo ESSALUD ( Site 2700)

    Arequipa, Ariqipa 04001
    Peru

    Site Not Available

  • Clinica Peruano Americana S.A. ( Site 2702)

    Trujillo, La Libertad 13011
    Peru

    Site Not Available

  • Hospital Militar Central [Lima, Peru] ( Site 2704)

    Lima, 15076
    Peru

    Site Not Available

  • Hospital Nacional Guillermo Almenara Irigoyen ( Site 2708)

    Lima, 15033
    Peru

    Site Not Available

  • Instituto de Oncologia y Radioterapia Clinica Ricardo Palma ( Site 2706)

    Lima, 15036
    Peru

    Site Not Available

  • Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 1716)

    Bydgoszcz, Kujawsko-pomorskie 85-796
    Poland

    Site Not Available

  • Szpital Uniwersytecki nr 1 im. Dr. Antoniego Jurasza w Bydgoszczy ( Site 1720)

    Bydgoszcz, Kujawsko-pomorskie 85-094
    Poland

    Site Not Available

  • Nasz Lekarz Przychodnie Medyczne ( Site 1718)

    Torun, Kujawsko-pomorskie 87-100
    Poland

    Site Not Available

  • Szpital Uniwersytecki w Krakowie ( Site 1707)

    Krakow, Malopolskie 30-688
    Poland

    Site Not Available

  • Radomskie Centrum Onkologii ( Site 1701)

    Radom, Mazowieckie 26-600
    Poland

    Site Not Available

  • Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1700)

    Przemysl, Podkarpackie 37-700
    Poland

    Site Not Available

  • Wojewodzki Szpital Specjalistyczny nr 4 w Bytomiu ( Site 1717)

    Bytom, Slaskie 41-902
    Poland

    Site Not Available

  • Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna

    Poznan, Wielkopolskie 61-848
    Poland

    Site Not Available

  • Szpital Wojewodzki im. Mikolaja Kopernika ( Site 1709)

    Koszalin, Zachodniopomorskie 75-581
    Poland

    Site Not Available

  • Twoja Przychodnia - Szczeciskie Centrum Medyczne ( Site 1721)

    Szczecin, Zachodniopomorskie 71-434
    Poland

    Site Not Available

  • Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 1810)

    Krasnoyarsk, Krasnoyarskiy Kray 660133
    Russian Federation

    Site Not Available

  • Russian Scientific Center of Roentgenoradiology ( Site 1800)

    Moscow, Moskva 117997
    Russian Federation

    Site Not Available

  • SBIH City clinical hospital named after D.D. Pletniov ( Site 1813)

    Moscow, Moskva 105077
    Russian Federation

    Site Not Available

  • Volga District Medical Center Federal Medical and Biological Agency ( Site 1805)

    Nizhny Novgorod, Nizhegorodskaya Oblast 603074
    Russian Federation

    Site Not Available

  • Omsk Clinical Oncology Dispensary ( Site 1809)

    Omsk, Omskaya Oblast 644013
    Russian Federation

    Site Not Available

  • Instituto Catalan de Oncologia - ICO ( Site 1901)

    Hospitalet de Llobregat, Barcelona 08908
    Spain

    Site Not Available

  • Hospital Josep Trueta ( Site 1900)

    Girona, Gerona 17007
    Spain

    Site Not Available

  • Hospital Universitario Lucus Augusti ( Site 1905)

    Lugo, 27003
    Spain

    Site Not Available

  • Hospital 12 de Octubre de Madrid ( Site 1903)

    Madrid, 28041
    Spain

    Site Not Available

  • Hospital Clinico San Carlos ( Site 1906)

    Madrid, 28040
    Spain

    Site Not Available

  • Hospital Universitario Ramon y Cajal ( Site 1902)

    Madrid, 28034
    Spain

    Site Not Available

  • Hospital Virgen de la Macarena ( Site 1904)

    Sevilla, 41071
    Spain

    Site Not Available

  • Kantonsspital Graubuenden ( Site 2003)

    Chur, Grisons 7000
    Switzerland

    Site Not Available

  • Kantonsspital St. Gallen ( Site 2000)

    St. Gallen, Sankt Gallen 9007
    Switzerland

    Site Not Available

  • CHUV (centre hospitalier universitaire vaudois) ( Site 2002)

    Lausanne, Vaud 1011
    Switzerland

    Site Not Available

  • Universitaetsspital Zuerich ( Site 2001)

    Zuerich, Zurich 8091
    Switzerland

    Site Not Available

  • Kaohsiung Chang Gung Memorial Hospital ( Site 0504)

    Kaohsiung, 83301
    Taiwan

    Site Not Available

  • National Cheng Kung University Hospital ( Site 0503)

    Tainan, 70457
    Taiwan

    Site Not Available

  • National Taiwan University Hospital ( Site 0500)

    Taipei, 100
    Taiwan

    Site Not Available

  • Taipei Veterans General Hospital ( Site 0501)

    Taipei, 11217
    Taiwan

    Site Not Available

  • Chang Gung Medical Foundation. Linkou ( Site 0502)

    Taoyuan, 333
    Taiwan

    Site Not Available

  • Chulalongkorn Hospital, Medical Oncology Unit ( Site 0600)

    Bangkok, Krung Thep Maha Nakhon 10330
    Thailand

    Site Not Available

  • Faculty of Medicine Siriraj Hospital ( Site 0602)

    Bangkok, Krung Thep Maha Nakhon 10700
    Thailand

    Site Not Available

  • Ramathibodi Hospital. ( Site 0601)

    Bangkok, Krung Thep Maha Nakhon 10400
    Thailand

    Site Not Available

  • Srinagarind Hospital ( Site 0604)

    Khon Kaen, 40002
    Thailand

    Site Not Available

  • Acibadem Adana Hastanesi ( Site 2106)

    Adana, 01130
    Turkey

    Site Not Available

  • Ankara Sehir Hastanesi ( Site 2103)

    Ankara, 06800
    Turkey

    Site Not Available

  • Ankara Universitesi Tip Fakultesi. ( Site 2101)

    Ankara, 06100
    Turkey

    Site Not Available

  • Hacettepe Universitesi Tıp Fakultesi ( Site 2105)

    Ankara, 06230
    Turkey

    Site Not Available

  • Istanbul Uni. Cerrahpasa Tip Fakultesi ( Site 2100)

    Istanbul, 34098
    Turkey

    Site Not Available

  • Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 2102)

    Izmir, 35100
    Turkey

    Site Not Available

  • Konya Necmettin Erbakan University Medical Faculty ( Site 2104)

    Konya, 42080
    Turkey

    Site Not Available

  • Aberdeen Royal Infirmary ( Site 1315)

    Aberdeen, Aberdeen City AB25 2ZN
    United Kingdom

    Site Not Available

  • Royal Cornwall Hospitals NHS Trust ( Site 1317)

    Truro, Cornwall TR1 3LJ
    United Kingdom

    Site Not Available

  • Royal Marsden NHS Foundation Trust ( Site 1318)

    London, London, City Of SW3 6JJ
    United Kingdom

    Site Not Available

  • University College London Hospitals NHS Foundation Trust ( Site 1320)

    London, London, City Of NW1 2BU
    United Kingdom

    Site Not Available

  • Velindre Cancer Centre Hospital ( Site 1322)

    Cardiff, CF14 2TL
    United Kingdom

    Site Not Available

  • Alaska Clinical Research Center ( Site 0274)

    Anchorage, Alaska 99503
    United States

    Site Not Available

  • Providence Alaska Medical Center ( Site 0276)

    Anchorage, Alaska 99508
    United States

    Site Not Available

  • City of Hope Medical Center ( Site 0217)

    Duarte, California 91010
    United States

    Site Not Available

  • UCLA Hematology/Oncology - Santa Monica ( Site 0241)

    Los Angeles, California 90404
    United States

    Site Not Available

  • UCLA Department of Medicine - Hematology & Oncology ( Site 0241)

    Santa Monica, California 90404
    United States

    Site Not Available

  • University of Colorado, Anschutz Cancer Pavilion ( Site 0236)

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Hartford HealthCare Medical Group ( Site 0212)

    Manchester, Connecticut 06042
    United States

    Site Not Available

  • Smilow Cancer Center at Yale-New Haven ( Site 0250)

    New Haven, Connecticut 06510
    United States

    Site Not Available

  • Sibley Memorial Hospital ( Site 0275)

    Washington, District of Columbia 20016
    United States

    Site Not Available

  • Winship Cancer Institute of Emory University ( Site 0209)

    Atlanta, Georgia 30322-1013
    United States

    Site Not Available

  • The University of Chicago ( Site 0264)

    Chicago, Illinois 60637
    United States

    Site Not Available

  • Springfield Clinic [Springfield, IL] ( Site 0240)

    Springfield, Illinois 62702
    United States

    Site Not Available

  • Cotton-O'Neil Cancer Center ( Site 0228)

    Topeka, Kansas 66606
    United States

    Site Not Available

  • The Sidney Kimmel Comprehensive Cancer Center ( Site 0204)

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • St. Vincent Frontier Cancer Center-Research ( Site 0213)

    Billings, Montana 59102
    United States

    Site Not Available

  • Comprehensive Cancer Centers of Nevada ( Site 0269)

    Las Vegas, Nevada 89169
    United States

    Site Not Available

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0270)

    New York, New York 10016
    United States

    Site Not Available

  • Weill Cornell Medical College ( Site 0263)

    New York, New York 10065
    United States

    Site Not Available

  • Associated Medical Professionals of NY ( Site 0251)

    Syracuse, New York 13210
    United States

    Site Not Available

  • Duke University ( Site 0206)

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Tri-State Urologic Services PSC, Inc. ( Site 0253)

    Cincinnati, Ohio 45212
    United States

    Site Not Available

  • MidLantic Urology ( Site 0273)

    Bala-Cynwyd, Pennsylvania 19004
    United States

    Site Not Available

  • Ralph H. Johnson VA Center ( Site 0256)

    Charleston, South Carolina 29401
    United States

    Site Not Available

  • Carolina Urologic Research Center ( Site 0259)

    Myrtle Beach, South Carolina 29572
    United States

    Site Not Available

  • Urology Associates [Nashville, TN] ( Site 0233)

    Nashville, Tennessee 37209
    United States

    Site Not Available

  • Inova Health System ( Site 0205)

    Fairfax, Virginia 22031
    United States

    Site Not Available

  • Urology of Virginia ( Site 0224)

    Virginia Beach, Virginia 23462
    United States

    Site Not Available

  • Seattle Cancer Care Alliance ( Site 0258)

    Seattle, Washington 98109
    United States

    Site Not Available

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