American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

Last updated: March 24, 2025
Sponsor: University of New Mexico
Overall Status: Active - Recruiting

Phase

N/A

Condition

Kidney Failure

Diabetes Prevention

Nephropathy

Treatment

N/A

Clinical Study ID

NCT04185844
19-159
  • Ages 21-80
  • All Genders

Study Summary

Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key risk factors for these diseases remain unanswered in the AI population. To address this burden of CKD in AI communities Investigators formed a consortium of investigators with extensive experience in conducting research of chronic diseases including diabetes, cardiovascular and kidney disease in AIs of Southwestern US. The proposed CRIC ancillary cohort study of 500 AIs (AI-CRIC) will rapidly improve our understanding of both potential risk factors for CKD progression, as well as the scope of this disease among AIs. This study leverages the current CRIC study and incorporates the planned activities of the next phase of the study

  • "CRIC 2018" - by implementing contemporary CRIC protocols for kidney and cardiovascular measurement and outcomes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Glomerular Filtration Rate (GFR): eGFR of =>61<80 and microalbuminuria > 30 or eGRFof =<60 (no microalbuminuria required).

Exclusion

Exclusion Criteria:

  1. Unable or unwilling to provide informed consent

  2. life expectancy <3 years;

  3. institutionalized subjects;

  4. End stage renal disease or renal transplant;

  5. renal cancer;

  6. myeloma;

  7. immunosuppression;

  8. Polycystic kidney disease;

  9. participation in any clinical trial,

  10. current pregnancy

  11. current incarceration.

  12. Appears unlikely or unable to participate in the required study procedures asassessed by the investigator, study coordinator or designee.

Study Design

Total Participants: 500
Study Start date:
August 31, 2020
Estimated Completion Date:
June 30, 2025

Study Description

Investigators will conduct a longitudinal study of a CKD cohort of Southwest AIs to identify unique risk factors for CKD and CVD progression and compare CKD and CVD event rates and risk factors between AI and the populations represented in CRIC. Investigators will establish a specimen bank to support future ancillary studies designed to identify and examine biomarkers associated with the progression of CKD in AIs.

At the Clinic Visit the following will occur:

  • weight is measured

  • blood pressure and heart rate are recorded

  • information about medical history and medication used recently

  • blood draw (about ½ cup) for the following tests: CBC (Complete Blood Count), tests of metabolism, and several other heart and kidney tests

  • blood pressure in the leg and arm calculated as the Ankle Brachial Index (ABI)

  • urine sample collection for kidney function testing

  • complete questionnaires about quality of life, diet, mood, thought processes and physical activity.

This visit takes about 1 to 2 hours. Participants will be contacted by telephone six months after the Baseline Visit to ask about recent medical events and medications.

Participants will be asked to return to the center for annual visits during which many but not all of the procedures described above will be conducted.

Additionally, participants will be asked to participate in one of two substudies using remote data collection techniques to identify trajectories of kidney function and cardiovascular risk sub-phenotypes

Connect with a study center

  • NIDDK-Phoenix Epidemiology and Clinical Research

    Phoenix, Arizona 85016
    United States

    Site Not Available

  • First Nations Community Health Source

    Albuquerque, New Mexico 87108
    United States

    Active - Recruiting

  • Zuni Health Initiative Center

    Black Rock, New Mexico 87327
    United States

    Active - Recruiting

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