The Effect of Permissive Hypercapnia on Oxygenation and Post-operative Pulmonary Complication During One-lung Ventilation

Last updated: December 30, 2019
Sponsor: Yonsei University
Overall Status: Active - Enrolling

Phase

N/A

Condition

Cardiac Surgery

Spinal Surgery

Thoracotomy

Treatment

N/A

Clinical Study ID

NCT04175379
4-2019-0904
  • Ages 40-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Permissive hypercapnia increased the survival rate in patients with acute respiratory distress syndrome (ARDS) who required mechanical ventilation in critical care medicine. This has been explained by its association with ventilator induced lung injury. Since then, a protective lung ventilation strategy has been very important, with a low tidal volume of 4-6 ml/kg. Patients undergoing surgery will inevitably require mechanical ventilation. In particular, patients undergoing one lung ventilation for thoracic surgery may have increased airway pressure and a greater chance of ventilator induced lung injury. Recently, protective lung ventilation has been applied to patients undergoing one ung ventilation during thoracic surgery. The purpose of this study is to evaluate the difference in the degree of pulmonary oxygenation and the incidence of postoperative pulmonary complications in hypercapnia induced by controlling the respiratory rate with a constant tidal volume.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Adult patients aged 40-80 years who are planning to have thoracoscopic singlelobectomy or segmentectomy with one lung ventilation during surgery.

  2. American Society of Anesthesiologists (ASA) classification 1~3

Exclusion

Exclusion Criteria:

  1. patients with heart failure (NYHA class III~IV)

  2. patients who are having moderate obstructive lung disease or restrictive lung disease

  3. Low DLCO (< 75%)

  4. patients with brain disease history or increased ICP

  5. patients with pulmonary hypertension (mean PAP>25mmHg)

  6. patients with liver disease (AST level ≥100 IU/mL or ALT ≥ level 50 IU/L) or kidneydisease (Creatine level ≥ 1.5 mg/dL)

  7. patients with pre-existing hypercapnia or metabolic acidosis

  8. body mass index (BMI) > 30 kg/m2

  9. patients who have had contralateral lung surgery

  10. patients who cannot read explanation and consent form

  11. patients who are pregnant

Study Design

Total Participants: 279
Study Start date:
November 25, 2019
Estimated Completion Date:
October 31, 2021

Connect with a study center

  • Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine

    Seoul, 03722
    Korea, Republic of

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.