Effectiveness of Platelet-rich Plasma for Treatment of Trigger Finger

Last updated: December 15, 2020
Sponsor: Töölö Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04167098
2845/2019
  • Ages 18-75
  • All Genders

Study Summary

Study purpose is to evaluate the effectiveness of Platelet-rich Plasma (PRP) injection in the treatment of trigger finger. We compare PRP to a corticosteroid (methylprednisolone) injection in a prospective randomized triple-blind placebo-controlled study.

Patients with clinically confirmed trigger finger are randomized (1:1:1 computer generated sequence with random block size) to three parallel groups and will receive an injection of either PRP, corticosteroid or placebo (0.9% saline) around the affected tendon sheath in a double-blind setting.

Baseline data is collected and is followed by a phone call at 1 month, and follow-up visits at 3, 6, 12 and 24 months after the intervention. Unveiling of the allocation is at 6 months post-intervention.

The primary outcome measures are:

  • Symptom resolution

  • Patient-Rated Wrist Evaluation

Secondary outcomes:

  • Quick-Disabilities of the Arm, Shoulder and Hand

  • Pain Visual Analogue Score

  • Global improvement (7-step Likert-scale)

  • Grip strength

  • Finger range of motion

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 - 75
  • Symptom duration > 3 months

Exclusion

Exclusion Criteria:

  • Diabetes
  • Rheumatoid arthritis or other condition requiring continuous oral corticosteroids
  • Previous history of surgery or injection to the affected ray
  • Alcohol or drug abuse
  • Mental instability

Study Design

Total Participants: 117
Study Start date:
November 01, 2019
Estimated Completion Date:
July 01, 2022

Connect with a study center

  • Töölö Hospital (Helsinki University Hospital)

    Helsinki,
    Finland

    Active - Recruiting

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