Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies

Last updated: June 20, 2025
Sponsor: BeiGene
Overall Status: Active - Enrolling

Phase

3

Condition

Neoplasms

Advanced Malignancies

Treatment

Sitravatinib

Temozolomide

Tislelizumab

Clinical Study ID

NCT04164199
BGB-A317-290-LTE1
2019-002554-23
  • Ages > 18
  • All Genders

Study Summary

This is an open-label, multicenter, extension study to evaluate the long-term safety and efficacy of BeiGene investigational drugs in participants with advanced malignancies who participated in a prior BeiGene-sponsored clinical study (parent study).

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Currently participating in a BeiGene-sponsored eligible parent study

  2. Fulfills treatment criteria specified in the parent study protocol

  3. In the opinion of the investigator, the participant will continue to benefit fromand tolerate any of the parent study treatments.

  4. The first dose of study treatment in the LTE study will be received within thetreatment interruption period allowed by the parent study:

  5. "Treatment interruption" (unplanned pause in study treatment) and "treatmentbreak" (planned stop of study therapy) are not interchangeable. Restartingstudy treatment beyond the interruption period allowed by the parent study orafter a treatment break will be determined by the investigator and the sponsor.Participants who have not restarted treatment within 1 year of starting atreatment break must discontinue treatment.

Specific Inclusion Criteria for Participants Who Continue Survival Follow-up Only in the Extension Study:

  1. Currently participating in a BeiGene-sponsored eligible parent study in the survivalfollow-up portion

  2. Parent study plans to have survival analysis

Exclusion

Key Exclusion Criteria:

  1. Permanently discontinued from all investigational drugs in the parent study due tounacceptable toxicity, noncompliance with study procedures, or withdrawal of consent

  2. Have uncontrolled active systemic infection or recent infection requiring parenteralantimicrobial therapy prior to the start of the extension study

  3. Have a life-threatening illness, medical condition, or organ system dysfunction thatin the investigator's opinion, could compromise the participant's safety, interferewith the absorption or metabolism of investigational drugs, or put the studyoutcomes at undue risk

  4. Underwent treatment with any systemic anticancer treatment (other than treatmentpermitted in the parent study) during the time between the last treatment in theparent study and the first dose of study treatment in the LTE study

  5. Pregnant or lactating women

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Study Design

Total Participants: 430
Treatment Group(s): 16
Primary Treatment: Sitravatinib
Phase: 3
Study Start date:
December 19, 2019
Estimated Completion Date:
December 31, 2026

Study Description

For the purposes of this study, "study treatment" will refer to all investigational agents. A parent study is defined as the original BeiGene-sponsored clinical trial in which the participant was initially enrolled and received BeiGene investigational drugs (with or without other treatments).

Connect with a study center

  • Prince of Wales Hospital

    Randwick, New South Wales 2031
    Australia

    Site Not Available

  • Northern Cancer Institute

    Saint Leonards, New South Wales 2065
    Australia

    Site Not Available

  • Northern Cancer Institute

    St Leonards, New South Wales 2065
    Australia

    Site Not Available

  • Calvary Mater Newcastle

    Waratah, New South Wales 2298
    Australia

    Site Not Available

  • Icon Cancer Care

    Brisbane, Queensland 4101
    Australia

    Site Not Available

  • Icon Cancer Care South Brisbane

    South Brisbane, Queensland 4101
    Australia

    Site Not Available

  • Icon Cancer Centre South Brisbane

    South Brisbane, Queensland 4101
    Australia

    Site Not Available

  • The Queen Elizabeth Hospital

    Woodville, South Australia 5011
    Australia

    Site Not Available

  • The Queen Elizabeth Hospital

    Woodville South, South Australia 5011
    Australia

    Site Not Available

  • Monash Health

    Clayton, Victoria 3168
    Australia

    Site Not Available

  • Peter Maccallum Cancer Centre

    Melbourne, Victoria 3000
    Australia

    Site Not Available

  • Chris O'Brien Lifehouse

    Camperdown, NSW 2050
    Australia

    Site Not Available

  • Peter MacCallum Cancel Centre

    East Melbourne,
    Australia

    Site Not Available

  • Anhui Provincial Cancer Hospital

    Hefei, Anhui 230088
    China

    Site Not Available

  • The Second Hospital of Anhui Medical University

    Hefei, Anhui 230601
    China

    Site Not Available

  • Beijing Cancer Hospital

    Beijing, Beijing 100142
    China

    Site Not Available

  • Cancer Hospital Chinese Academy of Medical Sciences

    Beijing, Beijing 100021
    China

    Site Not Available

  • Cancer Hospital Chinese Academy of Medical Sciences University(Xibei Hospital)

    Beijing, Beijing 100021
    China

    Site Not Available

  • Chinese PLA General Hospital

    Beijing, Beijing 100039
    China

    Site Not Available

  • Peking University First Hospital

    Beijing, Beijing 100034
    China

    Site Not Available

  • The Affiliated Hospital of Military Medical Sciences

    Beijing, Beijing 100071
    China

    Site Not Available

  • The fifth medical center of the General Hospital of the people's Liberation Army of China ( The 307th Hospital of Military Chinese People's Liberation Army )

    Beijing, Beijing 100071
    China

    Site Not Available

  • Chongqing Cancer Hospital

    Chongqing, Chongqing 400030
    China

    Site Not Available

  • Fujian Cancer Hospital

    Fuzhou, Fujian 350014
    China

    Site Not Available

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian 350001
    China

    Site Not Available

  • The First Affiliated Hospital of Xiamen University

    Xiamen, Fujian 361003
    China

    Site Not Available

  • Affiliated Cancer Hospital and Institute of Guangzhou Medical University

    Guangzhou, Guangdong 510030
    China

    Site Not Available

  • Cancer Center of Guangzhou Medical University

    Guangzhou, Guangdong 510030
    China

    Site Not Available

  • Guangdong General Hospital

    Guangzhou, Guangdong 510080
    China

    Site Not Available

  • Guangdong Provincial Peoples Hospital

    Guangzhou, Guangdong 510080
    China

    Site Not Available

  • Nanfang Hospital of Southern Medical University

    Guangzhou, Guangdong 510515
    China

    Site Not Available

  • Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North)

    Guangzhou, Guangdong 510000
    China

    Site Not Available

  • Sun Yat Sen Memorial Hospital, Sun Yat Sen University (South)

    Guangzhou, Guangdong 510245
    China

    Site Not Available

  • Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University

    Guangzhou, Guangdong 510120
    China

    Site Not Available

  • Sun Yat-sen University, Cancer Center

    Guangzhou, Guangdong 510060
    China

    Site Not Available

  • Cancer Hospital of Shantou University Medical College

    Shantou, Guangdong 515031
    China

    Site Not Available

  • The Fifth Affiliated Hospital Sun Yat Sen University

    Zhuhai, Guangdong 519000
    China

    Site Not Available

  • The Fifth Affiliated Hospital of Sun Yat-sen University

    Zhuhai, Guangdong 519099
    China

    Site Not Available

  • The Peoples Hospital of Guangxi Zhuang Autonomous Region

    Nanning, Guangxi 530021
    China

    Site Not Available

  • Nanfang Hospital

    Guangdong, Guangzhou 510515
    China

    Site Not Available

  • The Second Affiliated Hospital of Zunyi Medical University

    Zuiyi, Guizhou 550002
    China

    Site Not Available

  • Hainan Cancer Hospital

    Haikou, Hainan 570312
    China

    Site Not Available

  • Affiliated Hospital of Hebei University

    Baoding, Hebei 071000
    China

    Site Not Available

  • Affiliated Tumor Hospital of Harbin Medical

    Harbin, Heilongjiang 150000
    China

    Site Not Available

  • Harbin Medical University Cancer Hospital

    Harbin, Heilongjiang 150000
    China

    Site Not Available

  • Henan Cancer Hospital

    Zhengzhou, Henan 450000
    China

    Site Not Available

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan 450052
    China

    Site Not Available

  • Hubei Cancer Hospital

    Wuhan, Hubei 430079
    China

    Site Not Available

  • Hubei Cancer Hospital - Oncology

    Wuhan, Hubei 400037
    China

    Site Not Available

  • Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei 430030
    China

    Site Not Available

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei 430000
    China

    Site Not Available

  • Zhongnan Hospital of Wuhan University Wuhan

    Wuhan, Hubei 430071
    China

    Site Not Available

  • Hunan Cancer Hospital

    Changsha, Hunan 410013
    China

    Site Not Available

  • Xiangya Hospital of Central South University

    Changsha, Hunan
    China

    Site Not Available

  • The First Peoples Hospital of Changzhou

    Changzhou, Jiangsu 213000
    China

    Site Not Available

  • Jiangsu Province Hospital

    Nanjing, Jiangsu 210029
    China

    Site Not Available

  • The Affiliated Hospital of Xuzhou Medical University

    Xuzhou, Jiangsu 221000
    China

    Site Not Available

  • Xuzhou Central Hospital

    Xuzhou, Jiangsu
    China

    Site Not Available

  • Subei people's hospital (North Jiangsu people's hospital)

    Yangzhou, Jiangsu 225001
    China

    Site Not Available

  • The First Affiliated Hospital of Nanchang University Branch Donghu

    Nanchang, Jiangxi 330006
    China

    Site Not Available

  • The First affiliated hospital of Nanchang University

    Nanchang, Jiangxi 330006
    China

    Site Not Available

  • Jilin Cancer Hospital

    Changchun, Jilin 130021
    China

    Site Not Available

  • The First Hospital of Jilin University

    Changchun, Jilin 130021
    China

    Site Not Available

  • The first Bethune Hospital of Jilin University

    Changchun, Jilin 130021
    China

    Site Not Available

  • First Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning 116011
    China

    Site Not Available

  • The First Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning 116027
    China

    Site Not Available

  • Liaoning Cancer Hospital & Institute

    Shenyang, Liaoning 110042
    China

    Site Not Available

  • Liaoning Cancer Hospital and Institute

    Shenyang, Liaoning 110042
    China

    Site Not Available

  • The First Affiliated Hospital of Xian Jiaotong University

    Xian, Shaanxi 710061
    China

    Site Not Available

  • Qilu Hospital of Shandong University

    Jinan, Shandong 250012
    China

    Site Not Available

  • Shandong Cancer Hospital

    Jinan, Shandong 250117
    China

    Site Not Available

  • Weifang Peoples Hospital

    Weifang, Shandong 261000
    China

    Site Not Available

  • Affiliated Zhongshan Hospital of Fudan University

    Shanghai, Shanghai 200032
    China

    Site Not Available

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai 200000
    China

    Site Not Available

  • Shanghai Chest Hospital

    Shanghai, Shanghai 200030
    China

    Site Not Available

  • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

    Shanghai, Shanghai 200092
    China

    Site Not Available

  • Second Hospital of Shanxi Medical University

    Taiyuan, Shanxi 030001
    China

    Site Not Available

  • The First Affiliated Hospital Of Xi'an Jiao Tong University

    Xi'an, Shanxi 710061
    China

    Site Not Available

  • West China Hospital, Sichuan University

    Chengdu, Sichuan 610041
    China

    Site Not Available

  • West China Second University Hospital

    Chengdu, Sichuan 610101
    China

    Site Not Available

  • West China Second University Hospital, Sichuan University

    Chengdu, Sichuan 610101
    China

    Site Not Available

  • Institute of Hematology and Blood disease hospital,Chinese Academy of Medical Science

    Tianjin, Tianjin 300020
    China

    Site Not Available

  • Institute of Hematology and Hospital of Blood Disease

    Tianjin, Tianjin 300020
    China

    Site Not Available

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, Tianjin 300060
    China

    Site Not Available

  • Tianjin Medical University Cancer institute & Hospital

    Tianjin, Tianjin 300070
    China

    Site Not Available

  • Zhongnan Hospital of Wuhan University

    Wuhan, Wuhan 430071
    China

    Site Not Available

  • Affiliated Cancer Hospital of Xinjiang Medical University

    Urumqi, Xinjiang 830000
    China

    Site Not Available

  • Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang 310016
    China

    Site Not Available

  • The First Affiliated Hospital of College of Medicine, Zhejiang University

    Hangzhou, Zhejiang
    China

    Site Not Available

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang 310009
    China

    Site Not Available

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang 310022
    China

    Site Not Available

  • Zhejiang University College of Medicine Second Affiliated Hospital

    Hangzhou, Zhejiang 310009
    China

    Site Not Available

  • The First Provincial Wenzhou Hospital of Zhejiang

    Wenzhou, Zhejiang 325000
    China

    Site Not Available

  • Tongji Hospital of Tongji Medical College Huazhong University of Science Technology

    Wuhan, Hubei
    China

    Site Not Available

  • Hopital Beaujon

    Clichy, 92110
    France

    Site Not Available

  • Hopital Prive Jean Mermoz

    Lyon, 69008
    France

    Site Not Available

  • Icm Val Daurelle

    Montpellier, 34090
    France

    Site Not Available

  • Centre Hospitalier Universitaire Nantes Hotel Dieu

    Nantes, 44000
    France

    Site Not Available

  • Centre Hospitalier Universitaire Nantes Hotel Dieu

    Nantes Cedex, 44093
    France

    Site Not Available

  • Hopital Larchet Chu Nice

    Nice, 06200
    France

    Site Not Available

  • Policlinico Sorsola Malpighi, Aou Di Bologna

    Bologna, 40138
    Italy

    Site Not Available

  • Aou Pisana, Stabilimento Di Santa Chiara

    Pisa, 56126
    Italy

    Site Not Available

  • Azienda Ospedaliera S Maria Di Terni

    Terni, 05100
    Italy

    Site Not Available

  • Akita University Hospital

    Akitashi, Akita 010-8543
    Japan

    Site Not Available

  • Chiba Cancer Center

    Chibashi, Chiba 260-8717
    Japan

    Site Not Available

  • Nho Kyushu Cancer Center

    FukuokaShi, Fukuoka 811-1395
    Japan

    Site Not Available

  • Hokkaido University Hospital

    Sapporoshi, Hokkaido 060-8648
    Japan

    Site Not Available

  • Izumi City General Hospital

    Izumishi, Osaka 594-0073
    Japan

    Site Not Available

  • Osaka University Hospital

    Suitashi, Osaka 565-0871
    Japan

    Site Not Available

  • The University of Osaka Hospital

    Suitashi, Osaka 565-0871
    Japan

    Site Not Available

  • National Cancer Center Hospital

    ChuoKu, Tokyo 104-0045
    Japan

    Site Not Available

  • Cha Bundang Medical Center, Cha University

    BundangGu SeongnamSi, Gyeonggi-do 13496
    Korea, Republic of

    Site Not Available

  • Seoul National University Bundang Hospital

    BundangGu SeongnamSi, Gyeonggi-do 13620
    Korea, Republic of

    Site Not Available

  • National Cancer Center

    Goyangsi, Gyeonggi-do 10408
    Korea, Republic of

    Site Not Available

  • National Cancer Center (Korea)

    Goyangsi, Gyeonggi-do 10408
    Korea, Republic of

    Site Not Available

  • Cha Bundang Medical Center, Cha University

    Gyeonggido, Gyeonggi-do 13496
    Korea, Republic of

    Site Not Available

  • National Cancer Center (Korea)

    IlsandongGu GoyangSi, Gyeonggi-do 10408
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea, St Vincents Hospital

    PaldalGu SuwonSi, Gyeonggi-do 16247
    Korea, Republic of

    Site Not Available

  • Seoul National University Bundang Hospital

    Seongnamsi, Gyeonggi-do 13620
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea, St Vincents Hospital

    Suwonsi, Gyeonggi-do 16247
    Korea, Republic of

    Site Not Available

  • Gachon University Gil Medical Center

    Incheon, Incheon Gwang'yeogsi 21565
    Korea, Republic of

    Site Not Available

  • Gachon University Gil Medical Center

    NamdongGu, Incheon Gwang'yeogsi 21565
    Korea, Republic of

    Site Not Available

  • Chonnam National University Hwasun Hospital

    HwasunGun, Jeollanam-do 58128
    Korea, Republic of

    Site Not Available

  • Smg Snu Boramae Medical Center

    DongjakGu, Seoul Teugbyeolsi 07061
    Korea, Republic of

    Site Not Available

  • Samsung Medical Center

    GangnamGu, Seoul Teugbyeolsi 06351
    Korea, Republic of

    Site Not Available

  • Korea University Guro Hospital

    GuroGu, Seoul Teugbyeolsi 08308
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea, Seoul St Marys Hospital

    SeochoGu, Seoul Teugbyeolsi 06591
    Korea, Republic of

    Site Not Available

  • Severance Hospital Yonsei University Health System

    SeodaemunGu, Seoul Teugbyeolsi 03722
    Korea, Republic of

    Site Not Available

  • Asan Medical Center

    Seoul, Seoul Teugbyeolsi 05505
    Korea, Republic of

    Site Not Available

  • Korea University Guro Hospital

    Seoul, Seoul Teugbyeolsi 08308
    Korea, Republic of

    Site Not Available

  • Samsung Medical Center

    Seoul, Seoul Teugbyeolsi 06351
    Korea, Republic of

    Site Not Available

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi 03080
    Korea, Republic of

    Site Not Available

  • Severance Hospital Yonsei University Health System

    Seoul, Seoul Teugbyeolsi 03722
    Korea, Republic of

    Site Not Available

  • Smg Snu Boramae Medical Center

    Seoul, Seoul Teugbyeolsi 07061
    Korea, Republic of

    Site Not Available

  • The Catholic University of Korea, Seoul St Marys Hospital

    Seoul, Seoul Teugbyeolsi 06591
    Korea, Republic of

    Site Not Available

  • Asan Medical Center

    SongpaGu, Seoul Teugbyeolsi 05505
    Korea, Republic of

    Site Not Available

  • Ajou University Hospital

    Suwonsi, 16499
    Korea, Republic of

    Site Not Available

  • University Malaya Medical Centre

    Kuala Lumpur, 59100
    Malaysia

    Site Not Available

  • Sarawak General Hospital

    Kuching, 93586
    Malaysia

    Site Not Available

  • Auckland City Hospital

    Auckland, 1023
    New Zealand

    Site Not Available

  • Wellington Hospital

    Newtown,
    New Zealand

    Site Not Available

  • Szpitale Pomorskie Spolka Z Ograniczona Odpowiedzialnoscia

    Gdynia, 81-519
    Poland

    Site Not Available

  • Centrum Onkologii Instytut Im M Sklodowskiej Curie

    Warszawa, 02-781
    Poland

    Site Not Available

  • Chiayi Chang Gung Memorial Hospital

    Chiayi, 61363
    Taiwan

    Site Not Available

  • Linkou Chang Gung Memorial Hospital

    Guishan Dist, 33305
    Taiwan

    Site Not Available

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung, 83301
    Taiwan

    Site Not Available

  • Kaohsiung Chang Gung Memorial Hospital

    Niaosong Dist, 83301
    Taiwan

    Site Not Available

  • China Medical University Hospital

    North Dist, 404327
    Taiwan

    Site Not Available

  • National Cheng Kung University Hospital

    North Dist, 704
    Taiwan

    Site Not Available

  • China Medical University Hospital

    Taichung, 40447
    Taiwan

    Site Not Available

  • Taichung Veterans General Hospital

    Taichung City, 407
    Taiwan

    Site Not Available

  • Taichung Veterans General Hospital Gastroenterology

    Taichung City, 407
    Taiwan

    Site Not Available

  • Chi Mei Medical Center

    Tainan, 710
    Taiwan

    Site Not Available

  • National Cheng Kung University Hospital

    Tainan, 704
    Taiwan

    Site Not Available

  • National Taiwan University Hospital - Hematology And Oncology

    Taipei, 10048
    Taiwan

    Site Not Available

  • Chang Gung Memorial Hospital, Linkou

    Taoyuan, 33305
    Taiwan

    Site Not Available

  • Linkou Chang Gung Memorial Hospital

    Taoyuan, 33305
    Taiwan

    Site Not Available

  • Chi Mei Medical Center

    Yongkang Dist, 710
    Taiwan

    Site Not Available

  • King Chulalongkorn Memorial Hospital (Chulalongkorn University)

    Bangkok, 10330
    Thailand

    Site Not Available

  • King Chulalongkorn Memorial Hospital (Chulalongkorn University)

    Pathum Wan, 10330
    Thailand

    Site Not Available

  • Acibadem Adana Hospital

    Adana, 01130
    Turkey

    Site Not Available

  • Bakirkoy Sadi Konuk Eah

    IstanbulBakrkoy, 34147
    Turkey

    Site Not Available

  • Acibadem Adana Hospital

    Kurukopru, 01060
    Turkey

    Site Not Available

  • Namik Kemal University

    Tekirdag, 59100
    Turkey

    Site Not Available

  • Bakirkoy Sadi Konuk Eah

    stanbulBakrkoy, 34147
    Turkey

    Site Not Available

  • Mount Sinai Comprehensive Cancer Center

    Miami Beach, Florida 33140-2840
    United States

    Site Not Available

  • Mount Sinai Medical Center

    Miami Beach, Florida 33140
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center Mskcc

    New York, New York 10065-6800
    United States

    Site Not Available

  • Tennessee Oncology, Pllc Nashville

    Nashville, Tennessee 37203-1619
    United States

    Site Not Available

  • Baylor Research Institute

    Dallas, Texas 75246-2079
    United States

    Site Not Available

  • Texas Oncology

    Dallas, Texas 75246
    United States

    Site Not Available

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