The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression

Last updated: April 3, 2020
Sponsor: Chang Gung Memorial Hospital
Overall Status: Completed

Phase

4

Condition

Sleep Apnea Syndromes

Cerebral Ischemia

Stroke

Treatment

N/A

Clinical Study ID

NCT04162743
CMRPG2I0021
  • Ages > 20
  • All Genders

Study Summary

The investigators hypothesize that trazodone does not worse nocturnal oxygen saturation in insomnic ischemic stroke patients with obstructive sleep apnea (OSA) and depression and has beneficial effect in selected stroke patients with low arousal threshold phenotype OSA.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Insomnic ischemic stroke patients with OSA and depression.

Exclusion

Exclusion Criteria:

  • unclear consciousness, unstable vital sign or neurologic sign, unstable medicalconditions such as delirium, active infection, evidence of overt congestive cardiacfailure, liver dysfunction with ascites, thyroid disease, end-stage-renal-diseasereceiving dialysis.

  • overnight mean oxygen saturation (SaO2) nadir is ≤ 70% at baseline

  • take monoamine oxidase inhibitors (MAOI), any medication that may affect breathing,sleep, or muscle activity

  • any known allergy to trazodone

  • sleep disorder other than OSA (e.g., periodic leg movement syndrome, restless legssyndrome, central sleep apnea/Cheyne-Stokes respiration).

Study Design

Total Participants: 22
Study Start date:
February 01, 2019
Estimated Completion Date:
March 31, 2020

Connect with a study center

  • Chang Gung Memorial Hospital, Keelung

    Keelung,
    Taiwan

    Site Not Available

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