Brain Imaging of Cognition Inn Schizophrenia and Depression

Last updated: April 23, 2024
Sponsor: The Royal Ottawa Mental Health Centre
Overall Status: Active - Recruiting

Phase

N/A

Condition

Schizophrenia And Schizoaffective Disorders (Pediatric)

Tourette's Syndrome

Mood Disorders

Treatment

N/A

Clinical Study ID

NCT04159662
2018037
  • Ages 18-65
  • All Genders

Study Summary

Schizophrenia and depression are among the most disabling disorders in all of medicine. Cognitive deficits play a key role in patients' disability, affecting their capacity to contribute actively to society by sustaining employment or academic activity. Moreover, cognitive difficulties tend to persist even after the stabilization of other clinical symptoms. Verbal memory and emotion regulation are two important cognitive domains that are impaired in schizophrenia and depression and are associated with patients' functional outcomes. In this study, we are using brain imaging to investigate the brain mechanisms underlying these cognitive deficits in these populations.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age 18-65 years
  • current Intelligence Quotient (IQ) > 70 as measured by the Wechsler Abbreviated Scaleof Intelligence (WASI)
  • the ability to read and speak fluent English
  • a diagnosis of schizophrenia, schizoaffective or major depression disorder
  • stable medication for more than one month

Exclusion

Exclusion Criteria:

  • significant neurological or other medical disorders that may produce cognitiveimpairment
  • a recent history of substance abuse or dependence (within the past 3 months)
  • any magnetic resonance imaging (MRI) contraindications (e.g. metallic head implant,history of seizure, pacemaker)
  • decisional incapacity requiring a guardian
  • taking medications that are rated as Anticholinergic Burden (ACB) Score 3 (severe) ortaking benzodiazepines on a daily basis

Study Design

Total Participants: 90
Study Start date:
December 12, 2019
Estimated Completion Date:
October 01, 2026

Study Description

This study uses Functional Magnetic Resonance Imaging (fMRI) to help us better understand the cognitive problems that people who have schizophrenia, schizoaffective disorder, or depression experience. Cognitive problems can encompass a variety of different domains such as with attention, thinking, memory, emotion, and emotional regulation.

The study will involve three visits at The Royal's Institute of Mental Health Research. Each visit will last about 2.5 hours long.

Visits 1 and 2: We ask participants to fill out several questionnaires on a computer. We also ask participants to answer some questions about their current and past mental health. Participants will also perform some tasks involving general thinking skills.

Visit 3: This is the scan visit where we use fMRI, which is a technique that allows us to take a 3D picture of the brain using magnetic fields. It also allows us to estimate how active different regions of the brain are. During the fMRI, participants will lay down in a narrow tube in the fMRI scanner and hold still. Throughout the experiment, participant will perform three short tasks in the scanner, where they will see words and pictures and press a button to answer some questions.

Connect with a study center

  • Royal Ottawa Mental Health Center

    Ottawa, Ontario K1Z 7K4
    Canada

    Active - Recruiting

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