Phase
Condition
Leukemia
Cancer/tumors
Lymphoproliferative Disorders
Treatment
CART-ddBCMA
anitocabtagene-autoleucel
ARC-T Plus Anti-BCMA SparX
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Relapsed and refractory Multiple Myeloma treated with at least 3 prior regimens ofsystem therapy including Proteosome Inhibitor (PI), immunomodulatory drugs (IMiD),and anti-CD38 antibody (CD38mab); or has "triple-refractory" disease
Documented measurable disease
Adequate organ function
Life expectancy > 12 weeks, Eastern Cooperative Group Performance Status 0-1
Exclusion
Exclusion Criteria:
Plasma Cell Leukemia or History of Plasma Cell Leukemia
Patients with a history of severe hypersensitivity to DMSO should be excluded
Contraindication to fludarabine or cyclophosphamide
Severe uncontrolled intercurrent illness (e.g., infection) or laboratoryabnormalities
Active central nervous system disease involvement by malignancy or active CNSpathology
Study Design
Connect with a study center
Advanced Cellular Therapeutics Facility, DCAM 0800A
Chicago, Illinois 60637
United StatesSite Not Available
University of Chicago Medicine Comprehensive Cancer Center
Chicago, Illinois 60637
United StatesSite Not Available
Advanced Cellular Therapeutics Facility, DCAM 0800A
Chicago 4887398, Illinois 4896861 60637
United StatesSite Not Available
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02215
United StatesSite Not Available
Massachusetts General Hospital
Boston, Massachusetts 02114
United StatesSite Not Available
Beth Israel Deaconess Medical Center
Boston 4930956, Massachusetts 6254926 02215
United StatesSite Not Available
Massachusetts General Hospital
Boston 4930956, Massachusetts 6254926 02114
United StatesSite Not Available
Froedtert Hospital/Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United StatesSite Not Available
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United StatesSite Not Available
Froedtert Hospital/Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
United StatesSite Not Available

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