House Dust Mite Allergy Trial In Children

Inclusion Criteria:

• Male or female subjects aged 5-11 years

• A clinical history of HDM AR/C (Allergic rhinitis/rhinoconjunctivitis) (with orwithout asthma) and with allergic rhinitis symptoms despite having received allergypharmacotherapy during the previous year prior to screening

• Have a certain level of AR (Allergic rhinitis) symptoms on at least 8 of the last 14days of the baseline period

• Use symptomatic medication for treatment of HDM allergic rhinitis during at least 8of the last 14 days of the baseline period

• Positive skin prick test (SPT) and IgE (Immunoglobulin E) to D. pteronyssinus or D.farinae at screening

• Lung function ≥ 70% of predicted value

Exclusion Criteria:

• Sensitised and regularly exposed to perennial allergens

• Any nasal or pharyngeal condition that could interfere with the safety or efficacyevaluation

• Asthma requiring treatment with high dose of inhaled corticosteroid

• A relevant history of systemic allergic reaction