Phase
Condition
Tourette's Syndrome
Mood Disorders
Schizotypal Personality Disorder (Spd)
Treatment
Enriched Supportive Therapy
Cognitive Enhancement Therapy
Clinical Study ID
Ages 18-60 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Inclusion criteria will be evaluated longitudinally in a 4-week evaluation period. Patients will be included if they are outpatients and:
are between 18-60 years of age;
have a diagnosis of schizophrenia or schizoaffective disorder confirmed by the SCID;
have a clinical history of persistent negative symptoms lasting at least 3 months asidentified from the medical record;
have observed persistent negative symptoms at the beginning and end of the 4-weekevaluation period;
have been stabilized on antipsychotic medication at the beginning and end of the 4-week evaluation period;
have stabilized depressive symptoms at the beginning and end of the 4-weekevaluation period;
have mild or absent extrapyramidal symptoms at the beginning and end of the 4-weekevaluation period;
have had changes to their primary antipsychotic medication within the previous 3months;
have current IQ > 80; and
are able to read (sixth grade level or higher) and speak fluent English. -
Exclusion
Exclusion Criteria:
Exclusion criteria are intended to avoid likely treatment confounders and contraindications and include:
the presence of organic brain syndrome;
comorbid medical disorders producing cognitive impairment (e.g., mild brain injury,previous concussions with loss of consciousness);
persistent suicidal or homicidal behavior;
significant clinician-estimated medication non-adherence; and
SCID-verified substance use disorder.
Study Design
Study Description
Connect with a study center
University of Pittsburgh
Pittsburgh, Pennsylvania 15213
United StatesActive - Recruiting
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