Skeletal Muscle Energetics and Fatiguability in Older Individuals

Last updated: March 6, 2026
Sponsor: Johns Hopkins University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hiv Infections

Hiv

Treatment

N/A

Clinical Study ID

NCT04142047
IRB00197581
R01AG063661
  • Ages 60-90
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants who are >= 60 years of age

  • HIV serostatus positive participants on stable antiretroviral therapy (ART) (noregimen change in last month) with undetectable HIV viral load (<100 copies).

  • HIV serostatus negative participants

Exclusion

Exclusion Criteria:

  • Unable to understand the risks, benefits, and alternatives of participation and givemeaningful consent

  • Contraindications to MRI

  • Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease thatsignificantly limits exercise capacity

  • Significant lower extremity peripheral vascular disease.

  • Weight greater than 350 lbs

  • Cognitive or speech impairments that would limit completion of questionnaires orfatigue reporting.

Study Design

Total Participants: 200
Study Start date:
January 03, 2019
Estimated Completion Date:
July 01, 2027

Study Description

This research is being done to better understand why some older people living with HIV experience more fatigue and difficulty exercising than older people without HIV. This is important because fatigue and problems exercising are predictors of disability and hospitalization in older individuals. We will use non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) of the leg muscle to measure muscle metabolites and fat content, as well as blood samples measures levels of inflammation.

Connect with a study center

  • Johns Hopkins Hospital

    Baltimore, Maryland 21287
    United States

    Active - Recruiting

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