LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE

Inclusion Criteria:

• Ages 18-65 years

• Meets SLE diagnosis criteria

• Low suicide risk

• Not experiencing a manic episode

• Stable on all SLE and psychiatric medications for 6 weeks prior to screening

• Capacity to understand all relevant risks and potential benefits of the study

Exclusion Criteria:

• Drug-induced SLE and any other rheumatologic or autoimmune disease diagnosis (exceptfor Sjogren's syndrome and mixed connective tissue disease)

• Medical illness (unstable cardiac disease, AIDS, liver or renal impairment, ormalignant disease within 5 years before screening visit) or treatment of same thatcould interfere with study participation

• Neurological disorders, including but not limited to history of seizures (exceptchildhood febrile seizures and electroconvulsive therapy induced seizures),dementia, history of stroke, Parkinson's disease, multiple sclerosis, cerebralaneurysm; History of moderate to severe traumatic brain injury (TBI); Frequent orsevere migraines in the past 30 days before the screening visit

• History of positive hepatitis B, hepatitis C antibody, HIV antibody/antigen;Opportunistic infection in the 12 weeks before initial study dosing OR currentlyundergoing treatment for a chronic opportunistic infection (TB, pneumocystispneumonia, cytomegalovirus, herpes simplex virus, herpes zoster, or atypicalmycobacteria); Acute OR chronic infection requiring hospitalization in the 30 daysbefore screening visit AND/OR administration of parenteral (IV or IM) antibacterial,antiviral, antifungal, or anti-parasitic agents in the 30 days before screeningvisit

• Have received intravenous glucocorticoids at a dosage of ≥ 500mg daily within thepast month; Current use of benzodiazepines or anti-epileptic drugs

• History of thrombophlebitis or thromboembolic disorders (e.g., blood clots) orserious adverse reactions to blood draws

• Diagnostic and Statistical Manual of Mental Disorders (DSM-V) diagnosis of alcoholof substance abuse (other than nicotine) within the last month or a DSM-IV diagnosisof alcohol or substance dependence (other than nicotine) within the last 6 months;Prior or current diagnosis of bipolar disorder, manic episodes, hypomanic episodes,or mixed episodes; Prior or current diagnosis of a psychotic disorder

• Prior brain surgery; Any brain devices/implants, including cochlear implants andaneurysm clips or other factors that are contraindicated for undergoing an MRI

• Pregnancy, nursing, or if female and fertile, unwilling to use appropriate birthcontrol measures during study participation

• Concurrent medical condition or treatment for a medical disorder that, in theopinion of the investigator, could confound interpretation of results or affect thepatient's ability to fully participate in the study.

• Anything that, in the opinion of the investigator, would place the participant atincreased risk or preclude the participant's full compliance with or completion ofthe study

• Non-English speakers