Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2)

Last updated: April 23, 2024
Sponsor: Vanda Pharmaceuticals
Overall Status: Terminated

Phase

3

Condition

Skin Wounds

Allergies & Asthma

Skin Infections/disorders

Treatment

Placebo

Tradipitant

Clinical Study ID

NCT04140695
VP-VLY-686-3102
EPIONE2
  • Ages 18-70
  • All Genders

Study Summary

This is a multicenter, randomized, double-blind, placebo-controlled study to be conducted in the United States in subjects with atopic dermatitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male and non-pregnant, non-lactating female patients aged 18 - 70 years (inclusive);

  • Diagnosed with atopic dermatitis;

  • Suffering from chronic pruritus;

  • Body Mass Index (BMI) of ≥18 and ≤40 kg/m2

Exclusion

Exclusion Criteria:

  • Chronic pruritus due to condition other than atopic dermatitis (AD);

  • A positive test for drugs of abuse at the screening or evaluation visits;

  • Exposure to any investigational medication in the past 60 days

Study Design

Total Participants: 87
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 3
Study Start date:
October 21, 2019
Estimated Completion Date:
October 14, 2020

Connect with a study center

  • Vanda Investigational Site

    Birmingham, Alabama 35224
    United States

    Site Not Available

  • Vanda Investigational Site

    Hoover, Alabama 35244
    United States

    Site Not Available

  • Vanda Investigational Site

    Tempe, Arizona 85281
    United States

    Site Not Available

  • Vanda Investigational Site

    Encino, California 91436
    United States

    Site Not Available

  • Vanda Investigational Site

    Fountain Valley, California 92708
    United States

    Site Not Available

  • Vanda Investigational Site

    Laguna Hills, California 92653
    United States

    Site Not Available

  • Vanda Investigational Site

    Lomita, California 90717
    United States

    Site Not Available

  • Vanda Investigational Site

    Los Angeles, California 90025
    United States

    Site Not Available

  • Vanda Investigational Site

    Santa Monica, California 90404
    United States

    Site Not Available

  • Vanda Investigational Site

    Denver, Colorado 80220
    United States

    Site Not Available

  • Vanda Investigational Site

    Clearwater, Florida 33756
    United States

    Site Not Available

  • Vanda Investigational Site

    Miami, Florida 33126
    United States

    Site Not Available

  • Vanda Investigational Site

    Tampa, Florida 33613
    United States

    Site Not Available

  • Vanda Investigational Site

    Savannah, Georgia 31406
    United States

    Site Not Available

  • Vanda Investigational Site

    Boise, Idaho 83704
    United States

    Site Not Available

  • Vanda Investigational Site

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Vanda Investigational Site

    Normal, Illinois 61761
    United States

    Site Not Available

  • Vanda Investigational Site

    Skokie, Illinois 60077
    United States

    Site Not Available

  • Vanda Investigational Site

    Plainfield, Indiana 46168
    United States

    Site Not Available

  • Vanda Investigational Site

    Crowley, Louisiana 70526
    United States

    Site Not Available

  • Vanda Investigational Site

    Timonium, Maryland 21093
    United States

    Site Not Available

  • Vanda Investigational Site

    Towson, Maryland 21204
    United States

    Site Not Available

  • Vanda Investigational Site

    Fort Gratiot, Michigan 48059
    United States

    Site Not Available

  • Vanda Investigational Site

    Saint Joseph, Missouri 64506
    United States

    Site Not Available

  • Vanda Investigational Site

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Vanda Investigational Site

    Omaha, Nebraska 68144
    United States

    Site Not Available

  • Vanda Investigational Site

    Las Vegas, Nevada 89119
    United States

    Site Not Available

  • Vanda Investigational Site

    Berlin, New Jersey 08009
    United States

    Site Not Available

  • Vanda Investigational Site

    Hoboken, New Jersey 07030
    United States

    Site Not Available

  • Vanda Investigational Site

    Verona, New Jersey 07044
    United States

    Site Not Available

  • Vanda Investigational Site

    Bronx, New York 10458
    United States

    Site Not Available

  • Vanda Investigational Site

    Kew Gardens, New York 11415
    United States

    Site Not Available

  • Vanda Investigational Site

    New York, New York 10022
    United States

    Site Not Available

  • Vanda Investigational Site

    Charlotte, North Carolina 28277
    United States

    Site Not Available

  • Vanda Investigational Site

    Cincinnati, Ohio 45212
    United States

    Site Not Available

  • Vanda Investigational Site

    Oklahoma City, Oklahoma 73112
    United States

    Site Not Available

  • Vanda Investigational Site

    Tulsa, Oklahoma 74136
    United States

    Site Not Available

  • Vanda Investigational Site

    Philadelphia, Pennsylvania 19103
    United States

    Site Not Available

  • Vanda Investigational Site

    Johnston, Rhode Island 02919
    United States

    Site Not Available

  • Vanda Investigational Site

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

  • Vanda Investigational Site

    Dallas, Texas 75230
    United States

    Site Not Available

  • Vanda Investigational Site

    Houston, Texas 77004
    United States

    Site Not Available

  • Vanda Investigational Site

    Mesquite, Texas 75149
    United States

    Site Not Available

  • Vanda Investigational Site

    South Jordan, Utah 84095
    United States

    Site Not Available

  • Vanda Investigational Site

    West Jordan, Utah 84088
    United States

    Site Not Available

  • Vanda Investigational Site

    South Burlington, Vermont 05403
    United States

    Site Not Available

  • Vanda Investigational Site

    Alexandria, Virginia 22311
    United States

    Site Not Available

  • Vanda Investigational Site

    Newport News, Virginia 23606
    United States

    Site Not Available

  • Vanda Investigational Site

    Norfolk, Virginia 23502
    United States

    Site Not Available

  • Vanda Investigational Site

    Spokane, Washington 99202
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.