Nab-paclitaxel Plus Carboplatin Versus Nab-paclitaxel Plus Epirubicin in the Neoadjuvant Therapy for Breast Cancer

Phase

Condition

Cancer

Breast Cancer

Treatment

Nab-paclitaxel + Carboplatin

Nab-paclitaxel + Epirubicin

Clinical Study ID

NCT04138719

CSPC-KAL-BC-11

Ages 18-70
Female

Study Summary

This is a multicenter, open, randomized, comparison study. Triple-negative breast cancer (TNBC) is a term applied to breast cancer cases that have <1% expression of the estrogen receptor (ER) and the progesterone receptor (PR) and do not over express HER2.

Neoadjuvant therapy is often used to reduce the size of tumors, especially in locally advanced tumors. The purpose of this therapy is to make part of patients operable and to facilitate breast-conserving surgery.

The purpose of this study is to assess the efficacy and safety of the following two proposals: nab-paclitaxel plus carboplatin versus nab-paclitaxel plus epirubicin, in order to provide support for rational clinical application.

The total number of patients to be included in this study is 520 patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Females with age between 18 to 70 years old;
Histologically confirmed primary invasive breast cancer;
Histologically confirmed triple negative breast cancer;
Patients who planned to accept preoperative neoadjuvant therapy and had a masslarger than 2 cm.
Blood specimens and 5 sections of tumor tissue at baseline, blood specimens atsurgery can be obtained.
Have at least one measurable lesion as per the RECIST criteria (version 1.1);
Eastern Cooperative Oncology Group (ECOG) performance status less than or equal toone;
LVEF≥55%；
Bone marrow function：neutrophils (≥1.5×10^9/L), platelets (≥100×10^9/L), hemoglobin (≥90 g/L);
Renal and hepatic function: Serum creatinine≤ 1.5×institutional upper limit ofnormal (ULN); AST and ALT ≤ 2.5 × ULN; Total bilirubin≤1.5×ULN, or patients withGilbert's syndrome ≤ 2.5 × ULN;
Patients had good compliance with the planned treatment, understood the researchprocess and written informed consent.

Exclusion

Exclusion Criteria:

Previous treatment with any cytotoxic chemotherapy, endocrine therapy, biotherapy orradiotherapy;
Patients with heart disease above grade II (including grade II) identified by NewYork Heart Association (NYHA) scores;
Patients with severe systemic infection or other serious diseases;
Patients allergic to or intolerant of chemotherapeutic drugs or their adjuvants;
Patients with other malignant tumors in the past five years, except for curedcervical carcinoma in situ and non-melanoma skin cancer;
Pregnancy or lactation, as well as reproductive age patients who refused to takeappropriate contraceptive measures in the trial;
Participation in any trial drug treatment or another interventional clinical trial 30 days before first dose was given;
The researchers considered the patients who were not suitable for enrollment.

Study Design